活血化瘀汤治疗冠状动脉支架置入术后再狭窄临床观察

Huoxue Huayu Decoction in the Treatment of Restenosis after Percutaneous Coronary Intervention

目的探讨对冠状动脉支架置入(Percutaneous coronary intervention,PCI)术后再狭窄患者采用活血化瘀汤治疗的临床效果及对患者血清炎性因子水平的影响。方法选择山东省单县中心医院2020年1月—2020年12月收治的PCI术后再狭窄患者80例,按照随机数表法分为西医治疗的对照组与联合使用活血化瘀汤治疗的试验组,各40例。比较2组的临床疗效,以2组的肿瘤坏死因子α(TNF-α)、C反应蛋白(CRP)、白细胞介素-8(IL-8)、可溶性细胞间黏附因子-1(sICAM-1)、基质金属蛋白酶-9(MMP-9)水平评估患者的心肌损伤情况。结果试验组治疗总有效率为97.50%(39/40),高于对照组的77.50%(31/40),差异有统计学意义(P<0.05);治疗后试验组TNF-α、CRP、IL-8、sICAM-1、MMP-9水平均低于对照组,差异均有统计学意义(P<0.05)。结论对PCI术后再狭窄患者采用活血化瘀汤干预能够有效提高治疗效果,可改善机体炎性反应,能够减轻心肌损伤,值得推广。

Objective To investigate the clinical effect of Huoxue Huayu decoction on patients with restenosis after percutaneous coronary intervention(PCI)and its influence on the levels of serum inflammatory factors.Methods A total of 80 patients with restenosis after PCI admitted to Shanxian Central Hospital from January to December 2020 were divided into the control group treated with Western medicine and the experimental group treated with Huoxue Huayu decoction according to the random number table,with 40 cases in each group.The clinical effect of the two groups was compared.The levels of tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-8(IL-8),soluble intercellular adhesion factor-1(sICAM-1)and matrix metalloproteinase-9(MMP-9)in two groups were evaluated for myocardial injury.Results The total effective rate of the experimental group(97.50%,39/40)was higher than that of the control group(77.50%,31/40),and the difference was statistically significant(P<0.05).After treatment,the levels of TNF-α,CRP,IL-8,sICAM-1 and MMP-9 in the experimental group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion The intervention of Huoxue Huayu decoction in patients with restenosis after PCI can effectively improve the therapeutic effect,improve the body’s inflammatory response and reduce the myocardial injury.It is worthy of promotion.