溴己新联合头孢呋辛钠治疗小儿肺炎的效果及对肺功能、血气分析指标的影响

Effect of bromhexine combined with cefuroxime sodium in the treatment of pneumonia in children and its influences on lung function and blood gas analysis indexes

目的探讨溴己新联合头孢呋辛钠治疗小儿肺炎的效果。方法选取2019年1月至2021年3月我院收治的100例肺炎患儿作为研究对象,按照随机数字表法将其分为对照组和观察组,各50例。对照组采用头孢呋辛钠治疗,观察组在对照组基础上加用溴己新治疗。比较两组的治疗效果。结果观察组的治疗总有效率为96.00%,显著高于对照组的78.00%(P<0.05)。观察组的咳嗽停止、退热、肺部啰音消失及白细胞恢复正常时间均短于对照组(P<0.05)。治疗1周后,两组的第一秒用力呼气容积占预计值的百分比(FEV_(1)%)、用力肺活量占预计值的百分比(FVC%)及FEV_(1)/FVC高于治疗前,且观察组高于对照组(P<0.05)。治疗1周后,观察组的动脉血氧分压(PaO_(2))高于对照组,动脉血二氧化碳分压(PaCO_(2))低于对照组(P<0.05)。治疗1周后,观察组的白细胞介素-6(IL-6)、降钙素原(PCT)水平低于对照组,白细胞介素-10(IL-10)水平高于对照组(P<0.05)。两组的不良发应总发生率比较,差异无统计学意义(P>0.05)。结论溴己新联合头孢呋辛钠治疗小儿肺炎的效果显著,可提高肺功能,调节血气分析指标,减轻炎症反应,改善临床症状。

Objective To investigate the effect of bromhexine combined with cefuroxime sodium in the treatment of pneumonia in children.Methods A total of 100 children with pneumonia admitted in our hospital from January 2019 to March 2021 were selected as the research objects and divided into control group and observation group according to the random number table method,with 50 cases in each group.The control group was treated with cefuroxime sodium,and the observation group was treated with bromhexine on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was 96.00%,which was significantly higher than 78.00%in the control group(P<0.05).The cough stop,fever,lung rale disappearance and white blood cell recovery time in the observation group were shorter than those in the control group(P<0.05).After 1 week of treatment,the forced expiratory volume in one second as perventage of predicted value(FEV_(1)%),forced vital capacity as perventage of predicted value(FVC%)and FEV_(1)/FVC of the two groups were higher than those before treatment,and those of the observation group were higher than the control group(P<0.05).After 1 week of treatment,the arterial partial pressure of oxygen(PaO_(2))in the observation group was higher than that in the control group,and the arterial partial pressure of carbon dioxide(PaCO_(2))was lower than that in the control group(P<0.05).After 1 week of treatment,the levels of interleukin-6(IL-6)and procalcitonin(PCT)in the observation group were lower than those in the control group,and the level of interleukin-10(IL-10)was higher than that in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Bromhexine combined with cefuroxime sodium has a significant effect in the treatment of pneumonia in children,which can improve lung function,regulate blood gas analysis indexes,reduce inflammatory response and improve clinical symptoms.