炎症反应在卒中后认知功能障碍患者中的研究进展

Research advances in inflammatory response in patients with post-stroke cognitive impairment

卒中后认知功能障碍(post-stroke cognitive impairment,PSCI)是急性缺血性脑血管事件后常见的并发症之一,它不仅严重影响着卒中幸存者的生活质量,而且也增加了患者的死亡率。炎症反应(Inflammatory response)已经被证实参与急性缺血性卒中的发生和发展,它会损伤机体的神经细胞,使得机体的炎症反应更加活跃,释放出更多的炎症因子,破坏了神经环路的完整性,从而导致患者的认知功能障碍。既往的国内外研究探讨了炎症生物标志物与认知功能之间的关系,但关于两者关系的研究仍然较少,因此本文主要通过观察炎症生物标志物的水平变化来探讨炎症反应在PSCI患者中的作用。

Post-stroke cognitive impairment(PSCI)is a common complication following acute ischemic cerebrovascular events.It not only seriously affects the quality of life of stroke survivors,but also increases the mortality of the patients.Inflammatory response has been proven to participate in the development and progression of acute ischemic stroke,which injures neural cells to further activate the body's inflammatory response and release of inflammatory factors,destroy the integrity of neural circuits,and thereby lead to cognitive dysfunction in patients.Evidence on the relationship between inflammatory biomarkers and cognitive function is insufficient.Therefore,this paper focused on the changes in the levels of inflammatory biomarkers to discuss the role of inflammatory response in patients with PSCI.