血清AFR、FPR及NLR与早期结直肠癌患者术后辅助化疗疗效及预后的关系

Relationship Between Serum AFR,FPR and NLR and Efficacy and Prognosis of Postoperative Adjuvant Chemotherapy in Patients with Early Colorectal Cancer

目的 探讨血清白蛋白/纤维蛋白原比值(AFR)、纤维蛋白原/前白蛋白比值(FPR)及中性粒细胞计数与淋巴细胞计数比值(NLR)与早期结直肠癌患者术后辅助化疗疗效及预后的关系。方法 选取结直肠癌患者95例,治疗后根据临床疗效分为有效组和无效组,比较2组患者年龄、临床分期、组织学分型、肿瘤部位、AFR、FPR、NLR、淋巴结转移、肿瘤大小、分化程度等资料。再根据随访预后情况将有效组患者分为疾病进展组和疾病未进展组,比较2组患者不同病理资料。结果 患者经手术辅助化疗后,CR 56例,PR 22例,SD 15例,PD 2例,其中有效共78例(82.1%)。有效组与无效组患者年龄、临床分期、AFR、FPR、NLR、淋巴结转移、分化程度差异均具有统计学意义(P<0.05)。患者年龄、临床分期、AFR、FPR、NLR、淋巴结转移、分化程度是早期结直肠癌术后辅助化疗临床疗效的影响因素。随访18个月,有效组患者中疾病进展患者24例(30.8%),疾病进展组与疾病未进展组患者在年龄、临床分期、AFR、FPR、NLR、淋巴结转移、肿瘤大小、分化程度方面的差异均具有统计学意义(P<0.05)。患者年龄、临床分期、AFR、FPR、NLR、淋巴结转移、肿瘤大小、分化程度是早期结直肠癌术后辅助化疗临床预后的影响因素。结论 血清AFR、FPR、NLR是早期结直肠癌患者术后辅助化疗疗效及预后的影响因素,可用于观察早期结直肠癌患者术后辅助化疗疗效及判断预后。此外,早期结直肠癌患者术后辅助化疗疗效及预后与患者年龄、临床分期、淋巴结转移、分化程度等相关。

Objective To explore the relationship between serum albumin/fibrinogen ratio(AFR),fibrinogen/prealbumin ratio(FPR),neutrophil count/lymphocyte count ratio(NLR) and postoperative adjuvant chemotherapy efficacy and prognosis in patients with early colorectal cancer.Methods 95 patients with colorectal cancer were selected.After treatment,they were divided into effective group and ineffective group according to the clinical efficacy.The age,clinical stage,histological type,tumor location,AFR,FPR,NLR,lymph node metastasis,tumor size,differentiation degree and other data of the 2 groups were compared.According to the follow-up prognosis,the patients in the effective group were divided into progression-free survival(PFD) group and non-pFD group,and the different pathological data of the 2 groups were compared.Results After surgery and adjuvant chemotherapy,there were 56 cases of CR,22 cases of PR,15 cases of SD and 2 cases of PD,of which 78 cases were effective(82.1%).There were significant differences in age,clinical stage,AFR,FPR,NLR,lymph node metastasis and differentiation between the effective group and the ineffective group(P<0.05).The age,clinical stage,AFR,FPR,NLR,lymph node metastasis and differentiation degree of patients were the influencing factors of the clinical efficacy of adjuvant chemotherapy after surgery for early colorectal cancer.Following up for 18 months,there were 24 patients(30.8%) with disease progression in the effective group.There were significant differences in age,clinical stage,AFR,FPR,NLR,lymph node metastasis,tumor size and differentiation between the disease progression group and the disease non-progressive group(P<0.05).Patients' age,clinical stage,AFR,FPR,NLR,lymph node metastasis,tumor size and differentiation degree are the influencing factors of the clinical prognosis of adjuvant chemotherapy after surgery for early colorectal cancer.Conclusions Serum AFR,FPR and NLR are the factors that affect the efficacy and prognosis of adjuvant chemotherapy in patients with early colorectal cancer after surgery.They can be used to observe the efficacy and prognosis of adjuvant chemotherapy in patients with early colorectal cancer after surgery.The efficacy and prognosis of postoperative adjuvant chemotherapy in patients with early colorectal cancer are related to the age,clinical stage,lymph node metastasis and degree of differentiation of the patients.