CK5/6、Chk1表达在乳腺癌诊断及预后评估中的价值分析

Application of CK5/6 and Chk1 Expression in Breast Cancer Diagnosis and Prognostic Evaluation

目的 探讨CK5/6、Chk1表达在乳腺癌诊断及预后评估中的价值。方法 选取乳腺癌患者90例为研究组,另选取20例乳腺良性病变患者作为对照组。收集患者临床资料,免疫组化法检测乳腺癌及乳腺良性病变组织中CK5/6、Chk1的表达水平,分析与其临床病理特征、诊断和预后的关系。结果 CK5/6、Chk1表达与乳腺癌组织学分级有关(P<0.05),与乳腺癌患者年龄、淋巴结转移、肿瘤大小、组织学分级无关(P>0.05)。CK5/6、Chk1表达阴性患者的总生存率均显著高于阳性表达患者(P<0.05)。乳腺癌患者CK5/6、Chk1表达阳性率显著高于乳腺良性病变组(P<0.05)。ROC曲线分析可知,CK5/6、Chk1诊断乳腺癌AUC分别是0.701,0.729,联合检测AUC为0.803。结论 CK5/6、Chk1表达与乳腺癌临床病理特征有关,可能是影响患者预后的因素,且具有一定的诊断意义。

Objective To investigate the value of CK5/6 and Chk1 expression in the diagnosis and prognosis of breast cancer.Methods 90 patients with breast cancer were selected as the study group,and 20 patients with benign breast lesions were selected as the control group.The clinical data of patients were collected,the expression levels of CK5/6 and Chk1 in breast cancer and benign breast lesions were detected by immunohistochemistry,and the relationship between CK5/6 and clinicopathological features,diagnosis and prognosis was analyzed.Results The expressions of CK5/6 and Chk1 were correlated with the histological grade of breast cancer(P<0.05),but not with the age,lymph node metastasis,tumor size and histological grade of breast cancer patients(P>0.05).The overall survival rate of patients with negative CK5/6 and Chk1 expression were significantly higher than those with positive expression(P<0.05).The positive rates of CK5/6 and Chk1 in breast cancer patients were significantly higher than those in benign breast lesions group(P<0.05).ROC curve analysis showed that the AUC for CK5/6 and Chk1 diagnosis of breast cancer were 0.701 and 0.729,respectively,and the AUC for combined detection was 0.803.Conclusion The expressions of CK5/6 and Chk1 are related to the clinicopathologic features of breast cancer,which may be the prognostic factors of patients,and have certain diagnostic significance.