产复康颗粒联合卡前列甲酯栓治疗产后出血的效果观察

Effect of Chanfukang granules combined with carboprost methylate suppositories on postpartum hemorrhage

目的观察产复康颗粒联合卡前列甲酯栓治疗产后出血的效果。方法选取广西医科大学附属钦州市第二人民医院2015年1月至2021年12月收治的产后出血患者100例,根据随机数字表法分为对照组(50例)和观察组(50例)。对照组予卡前列甲酯栓阴道给药治疗,观察组在对照组基础上予产复康颗粒口服治疗。记录2组临床疗效、开始治疗后2、24 h出血量及止血时间,比较治疗前、治疗5 d后2组凝血功能、血常规、生活质量评定量表评分及不良反应发生情况。结果观察组总有效率高于对照组[94.0%(47/50)比76.0%(38/50)](χ^(2)=6.353,P=0.012)。观察组开始治疗后2、24 h出血量少于对照组,止血时间短于对照组[(1.98±0.24)d比(2.56±0.32)d](均P<0.001)。治疗5 d后,2组纤维蛋白原水平均低于治疗前,且观察组低于对照组(均P<0.05);2组血红蛋白、血细胞比容、红细胞计数水平均高于治疗前,且观察组均高于对照组(均P<0.05);2组物质生活、心理功能、躯体功能以及社会功能评分均高于治疗前,且观察组均高于对照组(均P<0.05)。2组不良反应发生率比较差异无统计学意义(P=0.749)。结论产复康颗粒联合卡前列甲酯栓治疗产后出血,可提高临床总有效率,有效改善血常规和凝血功能,减少产后出血量,缩短止血时间。

Objective To observe the effect of Chanfukang granules combined with carboprost methylate suppositories on postpartum hemorrhage.Methods From January 2015 to December 2021,100 patients with postpartum hemorrhage admitted to the Second People′s Hospital of Qinzhou,Guangxi Medical University were enrolled.They were divided into the control group(50 cases)and the observation group(50 cases).The control group was treated with carboprost methylate suppositories vaginally,and the observation group was treated with Chanfukang granules orally on the base of the control group.The clinical effect,bleeding volumes 2 and 24 h after treatment beginning and hemostatic time of two groups were recorded.The coagulation function,blood routine and quality of life rating scale score before treatment and 5 d after treatment as well as adverse reactions were compared between the two groups.Results The total effective rate in the observation group was higher than that in the control group[94.0%(47/50)vs 76.0%(38/50)](χ^(2)=6.353,P=0.012).Bleeding volumes 2 and 24 h after treatment beginning in the observation group were lower than those in the control group,and hemostatic time in the observation group was shorter than that in the control group[(1.98±0.24)d vs(2.56±0.32)d](all P<0.001).After 5 d of treatment,the levels of fibrinogen in both groups were lower than that before treatment,and the level in the observation group was lower than that in the control group(all P<0.05);levels of hemoglobin,hematocrit and red blood cell count in both groups were higher than those before treatment,and the levels in the observation group were higher than those in the control group(all P<0.05);scores of material life,psychological function,physical function and social function in both groups were higher than those before treatment,and the scores in the observation group were higher than those in the control group(all P<0.05).There was no difference in the incidence of adverse reactions between the two groups(P=0.749).Conclusions The combination of Chanfukang granules and carboprost methylate suppositories in the treatment of postpartum hemorrhage can improve the clinical total effective rate,effectively improve the blood routine and coagulation function,reduce the volume of postpartum hemorrhage,and shorten the hemostatic time.