肝癌自动计划中基于脚本实现角度优化的可行性研究

Feasibility Study of Beam Angle Optimization Based on Scripts in Automated-planning for Liver Cancer

目的 研究在肝癌自动计划中引入射野角度优化的可行性和潜在优势。方法 提出一种可嵌入Pinnacle自动计划模块Auto-planning的便捷角度优化方法,包含整体旋转射野角度,使用计划评分表(plan quality metric,PQM)进行评估并挑选最优计划。射野旋转和计划评分均由自制的Pinnacle脚本驱动,全流程可实现全自动。剂量学评估和医生评估作为PQM的补充被实施,并与PQM的结果进行了比较。结果 通过分析PQM的分值发现,只有15%患者的初始计划为最优计划。引入射野角度优化可以提高肝癌自动计划的质量。剂量学分析和医生评估都呈现了类似结果。结论 在自动计划中引入基于脚本的角度优化是可行的,从数值分析和医生评估中均可观察到该方法的优势。

Objective To study the feasibility and potential benefits of beam angle optimization(BAO) to automated planning in liver cancer.Methods An approach of beam angle sampling is proposed to implement BAO along with the module Auto-planning in treatment planning system(TPS) Pinnacle.An in-house developed plan quality metric(PQM) is taken as the preferred evaluating method during the sampling.The process is driven automatically by in-house made Pinnacle scripts both in sampling and scoring.In addition,dosimetry analysis and physician's opinion are also performed as the supplementary and compared with the result of PQM.Results It is revealed by the numerical analysis of PQM scores that only 15% patients whose superior trials evaluated by PQM are also the initial trials.Gantry optimization can bring benefit to plan quality along with auto-planning in liver cancer.Similar results are provided by both dose comparison and physician's opinion.Conclusion It is possible to introduce a full automated approach of beam angle optimization to automated planning process.The advantages of this procedure can be observed both in numerical analysis and physician's opinion.