钾离子通道在低氧性肺动脉高压中的作用及药物干预研究进展

Research progress on the role of potassium channels and drug intervention in hypoxic pulmonary hypertension

钾离子(K^(+))通道是位于细胞膜上的一种跨膜蛋白,血管平滑肌细胞K^(+)通道通过膜电位在血管张力、细胞兴奋性和细胞增殖等方面发挥重要调控作用。肺动脉平滑肌细胞K^(+)通道功能障碍与低氧性肺动脉高压(HPH)的病理进程密切相关,K^(+)通道有望成为HPH的治疗靶点。对肺动脉平滑肌细胞K^(+)通道的种类以及在HPH中的研究进展、相关干预药物进行综述,旨在为HPH的发病机制研究和药物研发提供新思路。

Potassium ion(K^(+))channel is a transmembrane protein located on cell membrane.The K^(+)channels of vascular smooth muscle cells play an important role in regulating vascular tension,cell excitability and proliferation through membrane potential.The dysfunction of K^(+)channels in pulmonary artery smooth muscle cells(PASMCs)is closely related to the pathological process of hypoxic pulmonary hypertension(HPH),and K^(+)channels are expected to become the therapeutic target of HPH.In this artical,types of K^(+)channels in PASMCs,the research progress of K^(+)channels in HPH and drugs that interfere with HPH were reviewed,in order to provide new ideas for the pathogenesis research and drug development of HPH.