玉屏风颗粒联合丙酸氟替卡松鼻喷雾剂对过敏性鼻炎患者ICAM-1、Th17/Treg的影响

Effects of Yupingfeng granules combined with fluticasone propionate nasal spray on ICAM-1 and Th17/Treg in patients with allergic rhinitis

目的探讨玉屏风颗粒联合丙酸氟替卡松鼻喷雾剂治疗过敏性鼻炎的效果。方法选择2019年1月至2021年4月收治的80例过敏性鼻炎患者为研究对象,根据随机数字表法将其分为对照组与观察组,各40例。对照组采用丙酸氟替卡松鼻喷雾剂治疗,观察组在对照组基础上加玉屏风颗粒治疗。比较两组的治疗效果。结果观察组的治疗总有效率高于对照组(P<0.05)。治疗后,观察组的细胞间黏附分子(ICAM-1)、血栓素B2(TXB2)、白三烯水平低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的调节性T细胞(Treg)高于对照组,辅助性T细胞17(Th17)、Th17/Treg低于对照组,差异具有统计学意义(P<0.05)。结论玉屏风颗粒联合丙酸氟替卡松鼻喷雾剂治疗过敏性鼻炎的效果满意,可调节ICAM-1、TXB2及白三烯表达,改善Th17/Treg,值得推广。

Objective To investigate the effect of Yupingfeng granules combined with fluticasone propionate nasal spray in the treatment of allergic rhinitis.Methods A total of 80 patients with allergic rhinitis admitted from January 2019 to April 2021 were selected as the research objects,according to the random number table method,the patients were divided into control group and observation group,with 40 cases in each group.The control group was treated with fluticasone propionate nasal spray,and the observation group was treated with Yupingfeng granules on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the levels of intercellular adhesion molecule-1(ICAM-1),thromboxane B2(TXB2)and leukotriene in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the regulatory T cells(Treg)in the observation group was higher than that in the control group,and the T helper cell 17(Th17)and Th17/Treg were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Yupingfeng granules combined with fluticasone propionate nasal spray has a satisfactory effect in the treatment of allergic rhinitis,it can regulate the expression of ICAM-1,TXB2 and leukotrienes,improve Th17/Treg,which is worthy of promotion.