血液循环肿瘤DNA在子宫颈癌中的研究进展

Progress of circulating tumor DNA in cervical cancer

子宫颈癌是妇女因癌症死亡的主要原因, 目前尚无可靠的无创指标来预测子宫颈癌的复发、转移及预后。循环肿瘤DNA(ctDNA)是肿瘤细胞释放进入血液循环中的DNA片段, 具有无创、实时、可反映肿瘤基因特征的优点。随着ctDNA检测技术的提升和对ctDNA研究的深入, ctDNA在子宫颈癌早期诊断、肿瘤分子分型、治疗监测及预测复发中表现出较传统组织学、血清学和影像学检测方法更明显的优势。文章就ctDNA的检测方法及其在子宫颈癌中的最新研究进展进行综述。

Cervical cancer is a leading cause of cancer death in women.There are no reliable noninvasive indicators to predict the recurrence,metastasis and prognosis of cervical cancer.Circulating tumor DNA(ctDNA)is a kind of DNA fragment released from tumor cells into the blood circulation,which has the advantages of being non-invasive,real-time,and of reflecting the genetic characteristics of tumors.With the improvement of ctDNA detection technology and in-depth research on ctDNA,ctDNA has shown more obvious advantages in early diagnosis,tumor molecular typing,treatment monitoring and recurrence prediction of cervical cancer compared with traditional histological,serological and imaging detection methods.This paper reviews the detection methods of ctDNA and its latest research progress of ctDNA in cervical cancer.