一项随访36个月接种宫颈疫苗女性HPV筛查的结果分析

Outcome analysis of HPV screening in a cohort of women vaccinated withcervical vaccine at 36 months follow-up

目的调查青春期及育龄期女性对HPV疫苗接种认知,随访接种HPV疫苗前后人乳头瘤病毒(HPV)筛查现状,对比HPV疫苗接种前后感染情况,能给予准确的干预意见。方法选取2019年1月至2022年12月该院妇科已接种HPV预防疫苗行HPV筛查的2170例女性作为研究对象。问卷调查法调查青春期及育龄期女性对HPV疫苗接种的认知情况,采用聚合酶链反应(PCR)结合脱氧核糖核酸(DNA)探针杂交法进行HPV感染分型检测,应用TCT进行细胞学检测,统计育龄期妇女接种疫苗前后HPV感染及转归情况。结果2170例研究对象中,认知良好者1837例(84.65%),认知不良者333例(15.35%)。问卷调查的每项问题认知比较,差异有统计学意义(P<0.05)。接种疫苗前有意识进行宫颈筛查的女性共112例(56%),接种后再进行宫颈筛查的女性43例(21.5%),仅45例(22.5%)女性在疫苗接种前后均有进行筛查。随后对45例接种疫苗前后宫颈筛查的育龄期妇女观察随访,发现34女性接种前后均无HPV病毒感染,仅11例(24.44%)疫苗接种后有HPV感染,其中1例HPV16持续阳性,2例TCT结果由ASCUS转归为LSIL,其余HPV及TCT结果正常。结论应提高育龄女性接种HPV疫苗认知意识及HPV感染的有效管理。

Objective To investigate the awareness of HPV vaccination among women of adolescence and reproductive age,follow-up the current status of human papillomavirus(HPV)screening before and after HPV vaccination,and contrast the infection before and after HPV vaccination,which can give accurate intervention opinions.Methods A total of 2170 women who had received HPV prophylaxis vaccination for HPV screening were selected as study subjects from January 2019 to December 2022 at Department of Gynecological in this hospital.Questionnaires were administered to investigate the awareness of HPV vaccination among women of adolescence and reproductive age,using polymerase chain reaction(PCR)coupled with deoxyribonucleic acid(DNA)probe hybridization for HPV infection typing,and TCT for cytology,to count HPV infection and outcomes before and after vaccination among women of reproductive age.Results Among the 2170 study subjects,1837 were cognitively good,84.65%,and 333 were cognitively poor,15.35%.Each question of the questionnaires by contrast was statistically significant(P<0.05).A total of 112(56%)women were conscious about cervical screening before vaccination,43(21.5%)women about cervical screening after vaccination,and only 45(22.5%)women had screening both before and after vaccination.Subsequent observational follow-up of 45 women of childbearing age who underwent cervical screening before and after vaccination revealed that 34 women had no HPV virus infection before and after vaccination,and only 11(24.44%)had HPV infection after vaccination,including one who was HPV16 persistently positive,two whose TCT results were normalized to LSIL by AS-CUS,and the remaining HPV and TCT results were normal.Conclusion It needs effectively improve awareness of HPV vaccine receipt among women of childbearing age and effective management of HPV infection.