阿莫西林克拉维酸钾序贯疗法治疗扁桃体炎的临床效果

Clinical effect of sequential therapy with amoxicillin-clavulanate potassium in the treatment of tonsillitis

目的 研究扁桃体炎患者行阿莫西林克拉维酸钾序贯疗法治疗的效果。方法 数据取自本院2021年3月-2022年3月收治的68例扁桃体炎患者,“入院先后顺序”分参照组(阿莫西林克拉维酸钾,n=34)、序贯组(阿莫西林克拉维酸钾序贯疗法,n=34),2组疗效比较。结果 用药前比较两组免疫指标、炎症因子无差异,P>0.05;用药后与参照组比较,序贯组CD4+、CD4+/CD8+值更高,CD8+值更低;IL-6、TNF-α及hs-CRP指标更低;退热、咳嗽消失、咽喉肿痛消失及痊愈时间更短;序贯组有效率(97.06%)高于参照组(82.35%),χ^(2)=3.981,P=0.046,P<0.05(具有统计学意义)。结论 阿莫西林克拉维酸钾序贯疗法治疗扁桃体炎患者可调节免疫、改善炎症程度,减缓不适、促进疾病痊愈,增强疗效、值得推崇。

Objective To study the effect of sequential therapy with amoxicillin and clavulanate potassium in patients with tonsillitis.Methods The data were collected from 68 patients with tonsillitis who were admitted to our hospital from March 2021 to March 2022,and were divided into the control group(amoxicillin-clavulanate potassium,n=34),the observation group(a Moxicillin-clavulanate potassium sequential therapy,n=34),the curative effect of the two groups was compared.Results There was no difference in immune indexes and inflammatory factors between the two groups before treatment,P>0.05;after treatment,compared with the control group,the CD4+,CD4+/CD8+values in the observation group were higher,and the CD8+value was lower;IL-6,TNF-αand The hs-CRP index was lower;fever,cough disappeared,sore throat disappeared and recovery time was shorter;the effective rate of the observation group(97.06%)was higher than that of the control group(82.35%),χ^(2)=3.981,P=0.046,P<0.05(statistically significant).Conclusion Amoxicillin-clavulanate potassium sequential therapy in the treatment of tonsillitis patients can regulate immunity,improve the degree of inflammation,relieve discomfort,promote disease recovery,and enhance the curative effect,which is worthy of praise.