阿立哌唑联合碳酸锂对青少年双相情感障碍共病非自杀性自伤临床疗效研究

Clinical Effect Study of Aripiprazole Combined with Lithium Carbonate on Bipolar Affective Disorder Comorbidity Nonsuicidal Self-injury

目的:研究和分析青少年双相情感障碍共病非自杀性自伤(NSSI)患者接受阿立哌唑与碳酸锂联合治疗的效果。方法:将福建省福州神经精神病防治院2022年2月—2023年1月收治的76例青少年双相情感障碍共病NSSI患者通过随机数字表法分成两组。对照组(n=38)采用碳酸锂治疗,观察组(n=38)应用阿立哌唑与碳酸锂联合治疗。比较两组治疗前后杨氏躁狂量表(YMRS)评分、汉密尔顿抑郁量表(HAMD-24)评分、Barratt冲动性量表(BIS-11)评分及NSSI行为发生情况、用药安全性。结果:治疗前两组YMRS和HAMD评分比较,差异均无统计学意义(P>0.05);治疗4、8周后,观察组各项评分均明显更低,差异均有统计学意义(P<0.05)。治疗前两组行动冲动性、认知冲动性、非计划冲动性评分及总分对比,差异均无统计学意义(P>0.05);治疗4、8周后,观察组各项评分均显著低于对照组,差异均有统计学意义(P<0.05)。治疗4、8周后,观察组NSSI行为发生率均显著低于对照组,差异均有统计学意义(P<0.05)。观察组用药不良反应总发生率高于对照组,但两组比较,差异无统计学意义(P>0.05)。结论:青少年双相情感障碍共病NSSI患者接受阿立哌唑联合碳酸锂治疗可有效缓解病情,有效控制其冲动性及NSSI行为,而且用药安全性较高。

Objective:To study and analyze the effect of Aripiprazole combined with Lithium Carbonate in patients with bipolar affective disorder comorbidity nonsuicidal self-injury(NSSI).Method:A total of 76 patients with bipolar affective disorder comorbidity NSSI who were admitted to Fuzhou Neuropsychiatric Hospital,Fujian Province from February 2022 to January 2023 were divided into two groups according to random number table method.The control group(n=38)was treated with Lithium Carbonate,the observation group(n=38)was treated with Aripiprazole combined with Lithium Carbonate.Young mania rating scale(YMRS)score,Hamilton depression scale(HAMD-24)score,Barratt impulsiveness scale 11th version(BIS-11)score before and after treatment,and NSSI behavior occurrence and medication safety were compared between the two groups.Result:Before treatment,there were no significant differences in YMRS and HAMD scores between the two groups(P>0.05).After 4 and 8 weeks of treatment,the scores of all items in the observation group were significantly lower,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in the scores of action impulsivity,cognitive impulsivity,non-planned impulsivity and total scores between the two groups(P>0.05).After 4 and 8 weeks of treatment,the scores of all items in the observation group were significantly lower than those in the control group,the differences were statistically significant(P<0.05).After 4 and 8 weeks of treatment,the incidences of NSSI behavior in observation group were significantly lower than those in control group,the differences were statistically significant(P<0.05).The total incidence of adverse drug reactions in the observation group was higher than that in the control group,but there was no statistical significance between the two groups(P>0.05).Conclusion:Patients with bipolar affective disorder comorbidity NSSI are treated with Aripiprazole combined with Lithium Carbonate,which can effectively alleviate the condition,effectively control impulsivity and NSSI behavior,and the medication safety is high.