醛固酮水平与心血管疾病研究进展

Research Progress of Aldosterone Level and Cardiovascular Disease

原发性醛固酮增多症是继发性高血压的常见病因,在原发性高血压、心力衰竭、心律失常、冠心病等心血管疾病患者中醛固酮水平同样升高。本文通过综述醛固酮在高血压、心力衰竭、心律失常、冠心病、阻塞性睡眠呼吸暂停、糖尿病、卒中、肾功能不全等疾病中的作用机制,探讨醛固酮水平对心血管系统的影响及临床价值,推断醛固酮受体拮抗剂通过降低醛固酮水平有望对上述疾病的治疗提供帮助。

Primary aldosteronism is a common cause of secondary hypertension.Aldosterone levels are also increased in patients with primary hypertension,heart failure,arrhythmia,coronary heart disease and other cardiovascular diseases.This article reviews the mechanism of aldosterone in hypertension,heart failure,arrhythmia,coronary heart disease,obstructive sleep apnea,diabetes,stroke,renal insufficiency and other diseases,discusses the effect of aldosterone level on cardiovascular system and its clinical value,and infers that aldosterone receptor antagonists may help the treatment of these diseases by reducing aldosterone level.