高频重复经颅磁刺激治疗帕金森病患者的效果

Effects of high frequency repetitive transcranial magnetic stimulation in treatment of Parkinson’s disease

目的:观察高频重复经颅磁刺激治疗帕金森病患者的效果。方法:回顾性分析2018年5月至2022年6月郑州市第三人民医院收治的93例帕金森病患者的临床资料,按治疗方法不同将其分为对照组(n=42)和观察组(n=51)。对照组采用多巴丝肼片治疗,观察组在对照组基础上采用高频重复经颅磁刺激治疗,比较两组治疗前后帕金森综合评分量表(UPDRS)评分、自主神经功能[自主神经症状量表(SCOPA-AUT)]评分、平衡功能[Berg平衡量表(BBS)]评分、功能性步行能力及预测跌倒风险[“起立-行走”计时测试(TUGT)]水平和不良反应发生率。结果:治疗后,两组精神行为和情绪、日常生活和能力、运动功能等UPDRS评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组SCOPA-AUT评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组BBS评分均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组TUGT时间均短于治疗前,且观察组短于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:在多巴丝肼片治疗基础上采用高频重复经颅磁刺激治疗帕金森病患者可降低UPDRS和SCOPA-AUT评分,缩短TUGT时间,提高BBS评分,其效果优于单纯多巴丝肼片治疗。

Objective:To observe effects of high frequency repetitive transcranial magnetic stimulation in treatment of patients with Parkinson’s disease.Methods:The clinical data of 93 patients with Parkinson’s disease admitted to the hospital from May 2018 to June 2022 were retrospectively analyzed.They were divided into control group(n=42)and observation group(n=51)according to different treatment methods.The control group was treated with Levodopa and Benserazide hydrochloride tablets,while the observation group was treated with high frequency repetitive transcranial magnetic stimulation on the basis of that of the control group.The unified Parkinson’s disease rating scale(UPDRS)score,the autonomic nerve function[autonomic nerve symptom scale(SCOPA-AUT)]score,the balance function[Berg balance scale(BBS)]score,the functional walking ability,the predictive fall risk[timed up and go test(TUGT)]level,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:After the treatment,the UPDRS scores of mental behavior and emotion,daily life and ability,and motor function in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The SCOPA-AUT scores of the two groups were lower than those before the treatment,that in the observation group was lower than that in the control group,and the differences were statistically significant(P<0.05).The BBS scores of the two groups were higher than those before the treatment,that in the observation group was higher than that in the control group,and the differences were statistically significant(P<0.05).The TUGT time of the two groups was shorter than that before the treatment,that in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:On the basis of Levodopa and Benserazide hydrochloride tablets,high frequency repetitive transcranial magnetic stimulation can reduce the UPDRS scores and the SCOPA-AUT scores,shorten the TUGT time and improve the BBS scores in the patients with Parkinson’s disease.Moreover,it is superior to single Levodopa and Benserazide tablets.