替硝唑联合阿莫西林克拉维酸钾治疗胃炎患儿的效果

Effects of Tinidazole combined with Amoxicillin and Clavulanate potassium in treatment of children with gastritis

目的:观察替硝唑联合阿莫西林克拉维酸钾治疗胃炎患儿的效果。方法:选取2019年1月至2022年3月该院收治的98例胃炎患儿进行前瞻性研究,按照随机数字表法将其分为观察组和对照组各49例。两组均予以保护胃黏膜、抑制胃酸分泌等治疗,在此基础上,对照组予以阿莫西林克拉维酸钾治疗,观察组在对照组基础上联合替硝唑治疗,连续治疗14 d。比较两组临床疗效、治疗前后T细胞亚群指标(CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))水平、炎性因子[白细胞介素-8(IL-8)、白细胞介素-17(IL-17)、可溶性白细胞介素-2受体(s IL-2R)]水平和不良反应发生率。结果:观察组治疗总有效率为97.96%(48/49),高于对照组的83.67%(41/49),差异有统计学意义(P<0.05);治疗后,观察组CD4^(+)、CD4^(+)/CD8^(+)水平均高于对照组,CD8^(+)水平低于对照组,差异有统计学意义(P<0.05);观察组s IL-2R、IL-8、IL-17水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:替硝唑联合阿莫西林克拉维酸钾治疗胃炎患儿可提高治疗总有效率,改善T细胞亚群指标水平,降低炎性因子水平,效果优于单纯阿莫西林克拉维酸钾治疗。

Objective:To observe effects of Tinidazole combined with Amoxicillin and Clavulanate potassium in treatment of children with gastritis.Methods:A prospective study was conducted on 98 children with gastritis admitted to the hospital from January 2019 to March 2022.They were divided into observation group and control group according to the random number table method,49 cases in each group.Both groups were treated to protect gastric mucosa and inhibit gastric acid secretion.On this basis,the control group was treated with Amoxicillin and Clavulanate potassium,while the observation group was treated with Tinidazole on the basis of that of the control group.The treatment lasted for 14 d continuously.The clinical efficacy,the levels of T cell subsets(CD4^(+),CD8^(+),CD4^(+)/CD8^(+))and inflammatory factors[interleukin-8(IL-8),interleukin-17(IL-17),soluble interleukin-2 receptor(sIL-2R)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 97.96%(48/49),which was higher than 83.67%(41/49)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of CD4^(+)and CD4^(+)/CD8^(+)in the observation group were higher than those in the control group,the level of CD8^(+)was lower than that in the control group,and the differences were statistically significant(P<0.05).The levels of sIL-2R,IL-8 and IL-17 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Tinidazole combined with Amoxicillin and Clavulanate potassium in the treatment of the children with gastritis can improve the total effective rate of treatment,improve the levels of T cell subsets and reduce the levels of inflammatory factors.Moreover,it is superior to single Amoxicillin Clavulanate potassium treatment.