子痫前期孕妇血清VEGF、sFlt-1水平与胎儿生长受限的相关性

Correlations among serum VEGF,sFlt-1 levels and fetal growth restriction in patients with preeclampsia

目的:分析子痫前期孕妇血清血管内皮生长因子(VEGF)、可溶性血管内皮生长因子受体-1(sFlt-1)水平与胎儿生长受限(FGR)的相关性。方法:回顾性分析2018年1月至2021年1月该院收治的60例子痫前期孕妇的临床资料,纳入研究组,收集同期于该院产检的60名健康孕妇的临床资料,纳入对照组。检测两组血清VEGF、sFlt-1水平,于分娩结束后统计研究组FGR发生情况,比较发生FGR孕妇与未发生FGR孕妇VEGF、sFlt-1水平,采用点二列相关性分析子痫前期孕妇血清VEGF、sFlt-1水平与FGR的相关性。结果:研究组血清VEGF水平低于对照组,sFlt-1水平高于对照组,差异均有统计学意义(P<0.05);60例子痫前期孕妇中发生FGR 16例,占26.67%(16/60);发生FGR孕妇血清VEGF水平低于未发生FGR孕妇,sFlt-1水平高于未发生FGR孕妇,差异均有统计学意义(P<0.05);点二列相关性分析结果显示,子痫前期孕妇血清VEGF水平与FGR呈负相关(r<0,P<0.05),sFlt-1水平与FGR呈正相关(r>0,P<0.05)。结论:子痫前期孕妇血清VEGF水平与FGR呈负相关孕妇sFlt-1水平与FGR呈正相关。

Objective:To analyze correlations among serum vascular endothelial growth factor(VEGF),soluble vascular endothelial growth factor receptor-1(sFlt-1)levels and fetal growth restriction(FGR)in patients with preeclampsia.Methods:The clinical data of 60 patients with preeclampsia admitted to the hospital from January 2018 to January 2021 were retrospectively analyzed and they were included in the study group.The clinical data of 60 healthy pregnant women who were examined in the hospital during the same period were collected and they were included in the control group.The serum VEGF and sFlt-1 levels were detected in both groups.The occurrence of FGR in the study group was determined after delivery.The levels of VEGF and sFlt-1 were compared among the patients with FGR and those without FGR.The correlation among the serum VEGF,sFlt-1 levels and FGR in the preeclampsia patients was analyzed by point biserial correlation analysis.Results:The serum VEGF level of the study group was lower than that of the control group,the sFlt-1 level was higher than that of the control group,and the differences were statistically significant(P<0.05).There were 16 cases of FGR in the 60 patients with preeclampsia,accounting for 26.67%(16/60).The level of serum VEGF in the patients with FGR was lower than that in the patients without FGR,the level of sFlt-1 was higher than that in the patients without FGR,and the differences were statistically significant(P<0.05).The point biserial correlation analysis showed that the serum VEGF level was negatively correlated with FGR in the preeclampsia patients(r<0,P<0.05),and the sFlt-1 level was positively correlated with FGR(r>0,P>0).Conclusions:The serum VEGF levels in the preeclampsia patients are negatively correlated with FGR,and the sFlt-1 levels are positively correlated with FGR.