单细胞测序在淋巴瘤中的研究进展

Progress of single-cell sequencing in lymphoma

单细胞测序(SCS)针对单个细胞的遗传信息进行测序,能更好地认识细胞之间的差异,揭示每种细胞类型独特的变化。在单细胞水平上对细胞亚群进行特异性分析,对肿瘤细胞和微环境细胞进行较精准的评估,从而揭示分子成分的复杂性以及与非恶性组织中相应成分的区别。淋巴瘤具有高度异质性,部分病理学分型不明、病因不清、预后不良。SCS技术有助于阐明淋巴瘤分子发生机制、病理分型并指导临床。文章就SCS及其在淋巴瘤中的应用进行综述。

Single-cell sequencing(SCS)sequences the genetic information of a single cell to better understand the differences amongst cells and reveal the unique changes of each cell type.The specific analysis of cell subsets at the single-cell level can accurately evaluate tumor cells and microenvironment cells to reveal the complexity of molecular components and the difference from the corresponding components in non-malignant tissues.Lymphoma is highly heterogeneous,some have unknown pathological types,etiology and poor prognosis.SCS is helpful to clarify the molecular mechanisms of lymphomagenesis and pathological staging,and guide clinical practice.This article reviews SCS and its application in lymphoma.