zeste基因增强子同源物2在血液系统肿瘤中的研究进展

Progress of enhancer of zeste homolog 2 in hematological tumors

zeste基因增强子同源物2(EZH2)是一种组蛋白甲基转移酶,在组蛋白甲基化修饰中研究较为广泛,其可促进基因的表观遗传学基因沉默,并通过多种调控机制介导肿瘤的发生。EZH2的功能获得和丧失突变在许多癌症中已被证实。目前,随着EZH2在表观遗传机制中的调控作用得到广泛重视,EZH2失调影响血液系统恶性肿瘤发病机制的确切方式仍有待阐明。文章对EZH2在血液系统肿瘤中的致病作用进行综述,以期为血液系统肿瘤的防治寻找新的靶点。

The enhancer of zeste homolog 2(EZH2)is a histone methyltransferase,which is widely studied in histone methylation modification.It can promote epigenetic gene silencing and mediate the occurrence of tumors through a variety of regulatory mechanisms.The gain-of-function and loss-of-function mutations of EZH2 have been confirmed in many cancers.At present,with the extensive attention paid to the regulatory role of EZH2 in epigenetic mechanism,the exact way in which EZH2 imbalance affects the pathogenesis of hematologic malignancies remains to be clarified.This article reviews the pathogenetic role of EZH2 in hematological tumors,and hope to find new targets for the prevention and treatment of hematological tumors.