刺激响应性分子印迹聚合物用于富集分析中药微量成分的研究进展

Progress in stimuli-responsive molecularly imprinted polymers for enrichment analysis of trace components in traditional Chinese medicine

分子印迹聚合物凭借特异性识别能力在有关微量成分的研究中脱颖而出。刺激响应性分子印迹聚合物(STR-MIPs)是在传统印迹材料的基础上通过分子结构设计引入不同种类的响应基团,当受到外界刺激如温度、磁性、pH或光照后会做出可逆变换的响应性行为,此响应性能结合特异性识别性能使STR-MIPs在微量成分研究中表现优异。中药成分复杂且含量稀少,利用STR-MIPs对中药微量成分进行富集分析的研究有着广阔的应用前景。基于此,该文从不同刺激因素的角度阐述各种刺激响应性分子印迹聚合物在中药微量成分富集分析中的应用,总结近五年的相关研究成果,为拓宽分子印迹应用领域提供参考,并对其未来的发展提出看法。

Molecularly imprinted polymers demonstrate outstanding performance in the research on trace ingredients because of their high selectivity.Stimuli-responsive molecularly imprinted polymers(STR-MIPs)with the introduction of different responsive groups on the basis of traditionally imprinted materials can undergo reversible transformations when exposed to external stimuli such as temperature,magnetism,pH or light.Such responsiveness,combined with the specific recognition,endows STR-MIPs with excellent performance in trace component studies.Traditional Chinese medicine(TCM)contains complex components with trace content,and thus STR-MIPs have broad application prospects in the enrichment analysis of trace components in TCM.This paper elaborates on the application of STR-MIPs in the enrichment analysis of trace components in TCM from the perspectives of different stimuli,summarized relevant research achievements in the recent five years to broaden the application fields of molecular imprinting,and proposed a few opinions about their future development.