颅底骨髓炎的诊断治疗进展

Current diagnosis and treatment of skull base osteomyelitis

颅底骨髓炎是罕见且难治的致死性疾病,其主要病因为耳源性和鼻源性感染,有时与恶性肿瘤不易区分。随着抗生素的应用,诊断方法和颅底外科手术技术的进步,死亡率较之前明显改善。然而,该病的成功诊治仍然充满挑战,其诊断易延误,治疗周期长、易反复,且缺乏相应指南。本文旨在系统地综述颅底骨髓炎的诊断治疗进展。

Skull base osteomyelitis is a rare,refractory,and potentially fatal disease primarily caused by otogenic and sino rhinogenic infections.At times,it can mimic neoplasia complicating the diagnosis.With the use of antibiotics,advancements in diagnostic methods,and skull base surgical techniques,the mortality rate has significantly improved.However,the successful diagnosis and treatment of the disease is still challenging due to delayed diagnosis,lengthy treatment course,a tendency for relapse and lack of guidelines.Therefore,this article aims to review the progress in the diagnosis and treatment of skull base osteomyelitis.