晚期胃癌治疗方法的研究进展和挑战

Advances and challenges in the treatment of advanced gastric cancer

胃癌是一种最常见的消化系统恶性肿瘤。目前,外科手术已成为根治胃癌的主要方法。随着外科技术的不断进步以及放疗、化疗、新的辅助疗法等手段的应用,早期胃癌患者5年生存率超过95%。但由于早期诊断率较低,大部分患者在确诊时已有较严重的病变,因此错过了最佳的治疗时机。目前,新辅助放化疗、分子靶向及免疫疗法是晚期胃癌的主要治疗手段。本文对近年来晚期胃癌的一些常用治疗手段进行了综述,并对其治疗进展进行了较详尽的论述。只有把临床研究与临床实践结合起来,才能使晚期胃癌患者得到有效的治疗;同时,重视患者的个体特征,合理用药,制订全面的治疗方案,提升治疗效果。

Gastric cancer is one of the most common malignant tumors of the digestive system.At present,surgery has become the main method of radical treatment of gastric cancer.With the continuous progress of surgical techniques and the application of radiotherapy,chemotherapy and new adjuvant therapies,the 5-year survival rate of early gastric cancer patients is more than 95%.However,due to the low early diagnosis rate,most patients have more serious lesions at the time of diagnosis,so the best treatment opportunity is missed.At present,neoadjuvant chemoradiotherapy,molecular targeting and immunotherapy are the main treatments for advanced gastric cancer.In this paper,some commonly used treatment methods for advanced gastric cancer in recent years are reviewed,and the progress of treatment is discussed in detail.Only by combining clinical research with clinical practice can advanced gastric cancer patients be effectively treated.At the same time,pay attention to the individual characteristics of patients,rational drug use,formulate a comprehensive treatment plan,and improve the treatment effect.