Advances in the study of gut microbiota affecting osteoporosis through SCFAs

The gut microbiota is closely associated with osteoporosis,but its specific mechanisms of action have not been fully elucidated.Short-chain fatty acids(SCFAs),produced by the fermentation of complex carbohydrates,are key regulatory metabolites produced by the gut microbiota and play an important role in the regulation of various systems by the gut microbiota.In recent years,SCFAs have been found to be a key link between the gut microbiota and bone.SCFAs can affect bone metabolism by affecting the integrity of the intestinal mucosal barrier,regulating G protein-coupled receptors and inhibiting histone deacetylase activity etc.SCFAs are currently the focus of research,but the mechanisms of interaction between SCFAs and osteoporosis in China are less reported.This paper reviews the role of gut microbiota and its metabolites,SCFAs,as well as the research progress of SCFAs affecting osteoporosis,with the aim of providing innovative therapeutic opportunities for bone metabolic diseases.