期刊文献+

The clinical impact of tricuspid regurgitation in patients with a biatrial orthotopic heart transplant

原文传递
导出
摘要 In this study,we aim to elucidate the clinical impact and long-term course of tricuspid regurgitation(TR),taking into account its dynamic nature,after biatrial orthotopic heart transplant(OHT).All consecutive adult patients undergoing biatrial OHT(1984−2017)with an available follow-up echocardiogram were included.Mixed-models were used to model the evolution of TR.The mixed-model was inserted into a Cox model in order to address the association of the dynamic TR with mortality.In total,572 patients were included(median age:50 years,males:74.9%).Approximately 32% of patients had moderate-to-severe TR immediately after surgery.However,this declined to 11%on 5 years and 9% on 10 years after surgery,adjusted for survival bias.Preimplant mechanical support was associated with less TR during follow-up,whereas concurrent LV dysfunction was significantly associated with more TR during follow-up.Survival at 1,5,10,20 years was 97%±1%,88%±1%,66%±2% and 23%±2%,respectively.The presence of moderate-to-severe TR during follow-up was associated with higher mortality(HR:1.07,95%CI(1.02–1.12),p=0.006).The course of TR was positively correlated with the course of creatinine(R=0.45).TR during follow-up is significantly associated with higher mortality and worse renal function.Nevertheless,probability of TR is the highest immediately after OHT and decreases thereafter.Therefore,it may be reasonable to refrain from surgical intervention for TR during earlier phase after OHT.
出处 《Frontiers of Medicine》 SCIE CSCD 2023年第3期527-533,共7页 医学前沿(英文版)
  • 相关文献

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部