丹参有效成分防治帕金森病药理机制研究进展

Research Progress in Pharmacological Mechanism of Salvia miltiorrhiza in Treatment of PD

帕金森病(PD)是严重威胁中老年人生命健康的神经退行性疾病之一,随着人口老龄化的不断进展,这一问题严重影响着患者及其照护者的生活质量,同时给家庭和社会造成巨大的经济负担。目前药物治疗是本病的主要治疗方式,然而随着病程的进展,传统药物的疗效往往不能满足临床需要,因此寻找安全有效的治疗方法迫在眉睫。丹参作为临床常用的传统中药,药理作用丰富多样,是治疗PD的高频用药。本文通过查阅近年来相关文献,系统梳理丹参活性成分治疗PD的作用机制,从抑制病理蛋白异常聚集、调节神经炎症、保护线粒体功能、减轻细胞凋亡、抗氧化应激、调节细胞自噬等方面进行综述,探讨药物递送系统并对未来研究方向进行展望,以期为相关基础和临床研究提供参考。

Parkinson s disease is one of the neurodegenerative diseases that endangers lives and health of adults in the middle-aged and aged people.With the aging population,this problem has a substantial impact on life quality of patients and their carers,meanwhile it poses a significant financial burden on families and society.The primary treatment for PD at the moment is medication therapy,but when the condition worsens,standard medications’clinical demands are frequently not addressed,which necessitates the urgent need for safe and efficient alternative therapies.Salvia miltiorrhiza,a traditional Chinese medicinal widely used in clinical practice,has a wide range of pharmacological effects,and multiple studies have demonstrated that it is a frequently used herb for PD.The mechanism of Salvia miltiorrhiza and its active components in treatment of PD was carefully studied in this research by reference to related literature.It was reviewed in terms of suppressing aberrant aggregation of pathogenic proteins,inhibiting neuroinflammation,protecting mitochondrial function,reducing apoptosis,resisting oxidative stress and regulating autophagy.The drug delivery method was described,as well as future research directions,in order to provide references for relevant scientific and clinical researches.