肠道菌群与儿童非酒精性脂肪性肝病的研究进展

Research Progress on Intestinal Microflora and Non-alcoholic Fatty Liver Disease in Children

儿童非酒精性脂肪性肝病(NAFLD)是全球儿童最常见慢性肝脏疾病,其发病率随着全球肥胖的流行而逐步上升,但缺乏规范、有效的治疗方案。目前其发病机制尚未完全阐明,在众多致病因素中,肠道菌群失调是目前的研究热点,为NAFLD的诊断、预防和治疗开辟了新的方向,但目前对儿童NAFLD的治疗仍在探索中。对近年来肠道菌群及其代谢产物介导儿童NAFLD的可能机制以及以肠道菌群为干预靶点的诊治方法进行综述,为儿童NAFLD的治疗提供一些新的思路及方法。

Pediatric non-alcoholic fatty liver disease(NAFLD)is the most common cause of pediatric chronic liver disease worldwide,and its incidence is gradually increasing with the global epidemic of obesity,but there is no standardized and effective treatment plan.At present,the pathogenesis of NAFLD has not been fully elucidated,Among many pathogenic factors,intestinal microflora disorder is the current research hotspot,which opens up a new direction for the diagnosis,prevention,and treatment of NAFLD.However,the treatment of NAFLD in children is still being explored.In this paper,the possible mechanism of intestinal flora and its metabolites mediating NAFLD in children in recent years was reviewed,as well as the diagnosis and treatment methods using intestinal flora as an intervention target,hoping to provide some new ideas and methods for the treatment of NAFLD in children.