心力衰竭的潜在治疗靶点及相关药物研发进展

Potential Therapeutic Targets and Research Progress of Related Drugs of Heart Failure

心力衰竭是心血管病主要死亡原因之一,随着心力衰竭患病率不断增加,探索寻找新的治疗靶点,进一步减少患者病死率,成为心力衰竭治疗的主要研究方向。主要通过对国内外发表的心力衰竭治疗靶点相关研究论文进行检索和整理,分类综述心力衰竭治疗的相关靶点,包括G蛋白偶联受体家族、Na+/H+交换体、去乙酰化酶家族、炎性细胞因子和趋化因子等,为心力衰竭治疗、新药研发提供新思路。

Heart failure is one of the main causes of death in cardiovascular diseases.With the increasing prevalence of heart failure,it has become the main research direction to explore new therapeutic targets and further reduce the mortality of patients.This review provided a comprehensive overview of the different targets for heart failure therapy,including the G protein-coupled receptor family,Na+/H+exchangers,deacetylase family,inflammatory cytokines and chemokines etc.,by searching and collating studies related to heart failure therapeutic targets published in China and abroad.It provided new ideas for the treatment of heart failure and the development of new drugs.