microRNAs对丙泊酚神经毒性的作用及机制研究进展

RESEARCH PROGRESS ON ROLE OF MICRORNAS IN PROPOFOL-INDUCED NEUROTOXICITY

儿童接触丙泊酚可能对神经元造成毒性损伤,并且与其成年后长期认知功能下降有关。其原因可能是由于多种机制诱导的神经细胞凋亡和抑制神经所致,其中microRNAs在这一过程中起着关键作用。本文对microRNAs在丙泊酚诱导的神经毒性作用中的作用和影响进行综述,为精准的脑神经保护提供参考依据。

Exposure to propofol in children may cause damage to neurons and even a long-term cognitive decline in adulthood.This may involve multiple mechanisms that induce neuronal apoptosis and neural inhibition,in which microRNAs play a key role.This paper reviews the role of microRNAs in propofol-induced neurotoxicity,aiming to provide a basis for precise cerebral neuroprotection.