典必殊联合奥洛他定滴眼液对儿童季节性过敏性结膜炎的影响

Effect of Tobradex eye drops combined with Olotadine eye drops on children with seasonal allergic conjunctivitis

目的:探讨应用典必殊滴眼液联合奥洛他定滴眼液对过敏性结膜炎的治疗效果。方法:眼科诊治的过敏性结膜炎儿童患者117例,随机分为观察组(59例)和对照组(58例),对照组患儿应用奥洛他定滴眼液治疗,观察组患儿应用典必殊联合奥洛他定滴眼液治疗。治疗2周后比较患儿的治疗效果、临床症状和体征,对比两组患儿的临床症状的消失时间、不良反应发生率,比较两组患儿治疗前后血清及泪液中透明质酸(hyaluronic acid,HA)、嗜酸细胞阳离子蛋白(eosinophil cationic protein,ECP)、免疫球蛋白E(immunoglobulin,IgE)的变化。结果:治疗后观察组的总有效率为89.83%,高于对照组患儿的70.69%(P<0.05);观察组患儿的临床症状及体征消失时间短于对照组(P<0.05);观察组和对照组的不良反应总发生率比较,差异无统计学意义(P>0.05);观察组和对照组患儿治疗后血清及泪液中HA、ECP、IgE水平均低于治疗前(P<0.05),且观察组低于对照组(P<0.05)。结论:典必殊联合奥洛他定滴眼液治疗儿童过敏性结膜炎,临床疗效优于单独使用奥洛他定滴眼液,值得推广。

Objective:To investigate the therapeutic effect of Tobradex eye drops combined with Olotadine eye drops on allergic conjunctivitis.Methods:A total of 117 children with allergic conjunctivitis diagnosed and treated by the ophthalmology department were randomly divided into observation group(59 cases)and control group(58 cases).The control group was treated with Olotadine eye drops,while the observation group was treated with Tobradex eye drops combined with Olotadine eye drops.After 2 weeks of treatment,the therapeutic effects,clinical symptoms and signs of the two groups were compared.The disappearance time of clinical symptoms and the incidence of adverse reactions were compared between the two groups.The changes of Hyaluronic acid(HA),Eosinophil cationic protein(ECP)and Immunoglobulin E(IgE)in serum and tears were compared between the two groups before and after treatment.Results:The total effective rate in the observation group was 89.83%,which was higher than that in the control group(70.69%)(P<0.05).The disappearance time of clinical symptoms and signs in observation group was shorter than that in control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between observation group and control group(P>0.05).After treatment,the levels of HA,ECP and IgE in serum and tear of observation group and control group were lower than those before treatment(P<0.05),and the observation group was lower than control group(P<0.05).Conclusion:The clinical efficacy of Tobradex combined with Olotadine in the treatment of allergic conjunctivitis in children is better than that of Olotadine,which is worth popularizing.