慢性心力衰竭急性失代偿期患者疗效与血清乙酰肝素酶和N端脑钠肽前体水平变化的相关性研究

Correlation between curative effect and changes of serum HPSE and NT-proBNP levels in patients with acute decompensated chronic heart failure

目的:观察慢性心力衰竭急性失代偿期(ADHF)患者治疗前后血清乙酰肝素酶(HPSE)水平变化,研究慢性心力衰竭患者疗效与血清HPSE水平变化的相关性。方法:选取住院的ADHF患者50名纳入心衰治疗组,同期住院的有基础心脏病但尚未达到心衰程度的30名患者作为试验对照组,以及同期体检的30名健康正常人纳入正常对照组。观察心衰治疗组治疗前后血清HPSE的变化及与N端脑钠肽前体(N terminal pro brain natriuretic peptide,NT-proBNP)的相关性。结果:心衰治疗后较治疗前血HPSE和NT-proBNP水平均明显降低(P<0.05);治疗前血清HPSE水平高于试验对照组及正常对照组;治疗后血清HPSE指标高于正常对照组(P<0.05),与试验对照组无显著差异(P>0.05)。Pearson相关分析提示治疗前后血HPSE和NT-proBNP水平呈正相关。结论:ADHF患者血清HPSE水平显著增高,纠正心衰后指标明显下降,且与血NT-proBNP水平呈正相关,血清HPSE水平可能与心衰严重程度有相关性。

Objective:To observe the changes of serum heparanase levels in patients with acute decompensated chronic heart failure before and after treatment,and to study the correlation between the efficacy and changes in serum HPSE levels in patients with chronic heart failure.Methods:Fifty hospitalized patients with ADHF were selected and included in the treatment group,30 patients with underlying heart disease but not yet reaching the level of heart failure who were hospitalized during the same period served as the experimental control group,and 30 healthy individuals who underwent physical examination during the same period were included in the normal control group.The changes of serum HPSE in patients with heart failure before and after treatment were detected by ELISA,and the relationship between NT-proBNP and serum heparanase in the treatment group before and after treatment and in the control group was observed.Results:After heart failure treatment,the levels of HPSE and NT-proBNP were significantly lower than those before treatment,and the difference was statistically significant(P<0.05).The level of serum HPSE before treatment was higher than that of the experimental and normal control groups,and the serum HPSE after treatment was higher than that of the normal control group.There was no significant difference with the experimental control group(P>0.05).Pearson correlation analysis indicated that blood HPSE and NT-proBNP levels were positively correlated before and after treatment.Conclusion:Serum HPSE levels were significantly higher in patients with ADHF,and the index decreased significantly after correction of heart failure,and was positively correlated with NT-proBNP levels;serum HPSE levels may be correlated with the severity of heart failure.