1例耐甲氧西林金黄色葡萄球菌引起皮肤软组织感染患儿抗感染治疗分析

Analysis of Anti-infective Treatment in a Child with Methicillin-resistant Staphylococcus Aureus Causing Skin Soft Tissue Infection

目的:分析应用万古霉素和利奈唑胺治疗耐甲氧西林金黄色葡萄球菌引起的皮肤软组织感染的效果,以及临床药师对患者用药的干预。方法:根据病原学检查结果、初始抗感染治疗方案等,分析1例耐甲氧西林金黄色葡萄球菌引起的皮肤软组织感染患儿抗菌药物使用情况。结果:在治疗患儿皮肤软组织感染过程中,组织分布是影响药物临床疗效的一个因素,万古霉素和利奈唑胺组织分布情况略有差异。相比于万古霉素,利奈唑胺属于亲脂性抗菌药物,主要分布在脂肪组织,更加适用于皮肤软组织感染。临床药师通过对该患儿实施药学监护,在治疗中给予医生、患儿家属相应的建议,通过开展药学监护保证患儿用药安全。结论:临床药师通过查房、会诊等方式参与患儿全程药学监护,为抗菌治疗提供方案及建议,也为临床药师参与复杂感染的抗菌治疗提供参考。

Objective:To analyze the effectiveness of applying vancomycin and linezolid for the treatment of soft tissue skin infections caused by methicillin-resistant Staphylococcus aureus and the intervention of clinical pharmacists in patient medication administration.Methods:One case of antimicrobial drug use in a child with methicillin-resistant Staphylococcus aureus-induced skin soft tissue infection was analyzed based on pathogenic findings and initial anti-infective treatment regimen.Results:In the treatment of soft tissue skin infections in children,tissue distribution was a factor that affects the clinical efficacy of the drug,with slight differences in the tissue distribution of vancomycin and linezolid.Compared with vancomycin,linezolid was a lipophilic antibacterial drug,mainly distributed in fatty tissues,and was more suitable for skin soft tissue infections.The clinical pharmacist ensures the safety of the child’s medication by implementing pharmacological monitoring of the child and giving appropriate advice to the doctor and the child’s family during treatment.Conclusion:Clinical pharmacists are involved in the whole pharmacological monitoring of children through room visits and consultations to provide protocols and recommendations for antimicrobial therapy,and also to provide reference for clinical pharmacists to participate in antimicrobial therapy for complex infections.