温度、pH双响应型P(NIPAAm-AAc-ABP)/SF复合纳米纤维膜的制备及驱动性能研究

Preparation and driving performance of P(NIPAAm-AAc-ABP)/SF composite nanofibrous membrane with temperature and pH dual response

通过自由基溶液聚合制得聚(N-异丙基丙烯酰胺-丙烯酸-丙烯酰氧基二苯甲酮)[P(NIPAAm-AAc-ABP)]三元共聚物,结合具有良好生物相容性的丝素蛋白(SF),通过静电纺丝技术制备了P(NIPAAm-AAc-ABP)/SF双层复合纳米纤维膜。利用核磁共振氢谱仪、傅里叶变换红外光谱仪、紫外-可见分光光度计、扫描电子显微镜等对共聚物和复合纳米纤维膜进行了结构、形貌和驱动性能表征。结果表明,通过实验合成了P(NIPAAm-AAc-ABP),且制备的复合纳米纤维膜纤维高度取向、直径均匀,经过紫外光交联的复合纳米纤维膜不溶于水。调整纤维的取向方向可得到横向收缩、螺旋状和卷曲成圈3种不同的驱动行为;改变温度和pH可控制复合纳米纤维膜的驱动程度;改变复合纳米纤维膜的厚度比可控制其响应时间和弯曲曲率;响应时间短(5~10s)且过程可逆。

Poly(N-isopropylacrylamide-acrylicacid-acryloyloxybenzophenone)[P(NIPAAm-AAc-ABP)]terpolymer was prepared by free radical solution polymerization.By using electrospun technique,P(NIPAAm-AAc-ABP)/SF bilayer composite nanofibrous membranes were prepared combining silk fibroin(SF)with good biocompatibility.The structure,morphology and driving performance of the copolymer and composite membranes were characterized by nuclear magnetic resonance spectroscopy(1H-NMR),Fourier transform infrared spectrometer(FT-IR),UV-Vis spectrophotometer(UV-Vis)and scanning electron microscopy(SEM).The results showed that P(NIPAAm-AAc-ABP)was successfully synthesized by experiment,the fibers of membranes were highly oriented and uniform in diameter,and the composite nanofiber membrane was insoluble in water after UV crosslinking.By adjusting the orientation direction of the fibers,three different driving behaviors could be obtained:transverse shrinkage,spiral and coil forming.The driving degree of composite membranes could be controlled by changing temperature and pH.The response time and bending curvature of the composite membranes could be controlled by changing the thickness ratio of the bilayer composite membranes,moreover,the response time was short(5~10s)and the process was reversible.