黄芩汤联合足三里穴化脓灸对结肠癌化疗患者胃肠道不良反应和免疫功能的影响

Effects of Huangqin Decoction Combined with Purulent Moxibustion at Zusanli Acupoint(ST ST3636)on Chemotherapy of Colon Cancer

目的探讨黄芩汤联合足三里穴化脓灸对结肠癌化疗患者胃肠道不良反应和免疫功能的影响。方法将中国医科大学附属第一医院2020年4月—2021年7月收治的82例结肠癌患者随机分为对照组(41例)和试验组(41例)。对照组化疗的同时给予黄芩汤治疗,共3个周期;试验组在对照组基础上给予足三里穴化脓灸治疗,共2个疗程。比较2组胃肠道不良反应发生率、免疫功能指标、卡氏(KPS)评分及生活质量评分表(QOL)评分。结果与对照组比较,试验组化疗后Ⅰ~Ⅱ度和Ⅲ~Ⅳ度恶心呕吐、食欲减退、腹泻等胃肠道不良反应的发生率较低,血CD4+T淋巴细胞水平及CD4+/CD8+比值较高,CD8+T淋巴细胞水平较低,KPS评分及QOL评分较高(P<0.05)。结论黄芩汤联合足三里穴化脓灸能明显减轻结肠癌化疗患者的胃肠道不良反应,提高免疫功能,改善生存及生活质量。

Objective To investigate the effects of Huangqin decoction combined with purulent moxibustion at Zusanli(ST36)on gas-trointestinal side effects and immune function in patients with colon cancer undergoing chemotherapy.Methods 82 patients with colon cancer admitted to the first hospital affiliated to China medical university from April 2020 to July 2021 were randomly divided into control group and treatment group on average.The control group was treated with Huangqin decoction while receiving chemotherapy for 3 cycles,and the treatment group was treated with purulent moxibustion at Zusanli(ST36)on the basis of the control group for 2 courses.The incidence of gastrointestinal side effects,immune function indexes,Karnofsky(KPS)score and quality of life(QOL)scale score were compared between the two groups.Results Compared with the control group,the incidence of gastrointestinal side effects such as grade I~II and grade III~IV nausea and vomiting,anorexia and diarrhea in the treatment group were lower.The levels of blood CD4+T lymphocytes and the ratio of CD4+/CD8+were higher,and the level of CD8+T lymphocytes was lower in the treatment group.The KPS and QOL score were higher in the treatment group after chemotherapy(P<0.05).Conclusion Huangqin decoction combined with purulent moxibustion at Zusanli(ST36)can significantly reduce gastrointestinal side effects,improve immune function,survival and quality of life in patients with colon cancer undergoing chemotherapy.