摘要
肾细胞癌是泌尿系统常见的肿瘤之一。尽管肾细胞癌发病率在世界范围内一直居高不下,但是得益于腹腔镜技术的发展以及靶向药物的应用,癌症的控制和患者的生存率取得了一定的改善。最新研究证实肾细胞癌的进展与肿瘤免疫微环境中的细胞代谢相关。因此在现有手术、免疫治疗的基础上,探求靶向肿瘤细胞代谢途径、干扰肿瘤细胞微环境的新型代谢疗法会为肾细胞癌提供一种独特的治疗方案。
Renal cell carcinoma is one of the common tumors in the urinary system.Despite the high incidence of renal cell carcinoma worldwide,progress has been made in cancer control and patients'survival profits from advances in laparoscopic technology and the application of targeted drugs.Recent studies have confirmed that the progression of renal cell carcinoma is related to cellular metabolism in the tumor microenvironment.Therefore,based on the existing surgical treatment and immunotherapy,exploring new metabolic therapies that target the metabolic pathway of tumor cells and interfere with the microenvironment of tumor cells will provide a unique treatment for renal cell carcinoma.
作者
胡玮璟
吴波
王东文
Hu Weijing;Wu Bo;Wang Dongwen(The First Clinical Medical College of Shanxi Medical University,Taiyuan 030001,China;Department of Urology,the First Hospital of Shanxi Medical University,Taiyuan 030001,China;Department of Urology,Shenzhen Hospital,Cancer Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,National Cancer Center,National Clinical Research Center for Cancer,Shenzhen 518172,China)
出处
《肿瘤研究与临床》
CAS
2023年第6期469-472,共4页
Cancer Research and Clinic
基金
山西省归国留学人员科研基金(2021-160)
山西省“1331工程”重点创新团队建设计划(3c332019001)。
关键词
细胞代谢
代谢转化
肿瘤微环境
肾细胞癌
Cellular metabolism
Metabolic transformation
Tumor microenvironment
Renal cell carcinoma
