血清胆红素与尿酸水平对冠心病的诊断价值分析

Analysis of Diagnostic Value of Serum Bilirubin and Uric Acid Levels for Coronary Heart Disease

目的:研究血清胆红素和尿酸(UA)水平诊断冠心病的价值。方法:选取2019年3月—2021年3月南京市高淳人民医院检验科受检者80例作为研究对象,根据检查结果分为观察组(冠心病患者)与对照组(健康人群),各40例。比较两组患者UA和血清胆红素水平,并根据冠状动脉狭窄程度积分,将观察组分成4级,比较各级UA和血清胆红素水平。结果:观察组UA水平高于对照组,总胆红素(TBiL)、直接胆红素(DBiL)、间接胆红素(IBiL)水平低于对照组,差异有统计学意义(P<0.001)。心功能级别越高,观察组UA水平越高,TBiL、DBiL、IBiL水平越低,差异有统计学意义(P<0.001)。UA、TBiL、DBiL、IBiL诊断冠心病的受试者操作特征曲线下面积分别为0.952、0.854、0.831、0.842,诊断价值较高。结论:针对冠心病患者,采用血清胆红素、UA水平进行诊断的价值显著;冠心病患者心功能级别越高,UA水平越高,血清胆红素水平越低,UA和血清胆红素可以作为诊断以及评估冠心病病情的重要指标,可指导临床医师制定合理的治疗方案。

Objective:To study the value of serum bilirubin and uric acid(UA)in the diagnosis of coronary heart disease.Methods:A total of 80 patients who underwent examination at the Clinical Laboratory Department of Nanjing Gaochun People's Hospital from March 2019 to March 2021 were selected as the study subjects.They were divided into an observation group(coronary heart disease patients)and a control group(health population)based on the examination results,with 40 patients in each group.The serum bilirubin and UA levels were compared between two groups of patients.The observation group was divided into four levels based on the score of coronary artery stenosis.The serum bilirubin and UA levels were compared among different levels.Results:The UA levels in the observation group were higher than those in the control group,while the total bilirubin(TBiL),direct bilirubin(DBiL)and indirect bilirubin(IBiL)levels in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).The higher level of cardiac function was associated with the higher UA level and the lower TBiL,IBiL,and DBiL levels in the observation group,with statistically significant differences(P<0.05).The areas under receiver operating characteristic curve for the UA,TBiL,DBiL and IBiL in diagnosing coronary heart disease were 0.952,0.854,0.831 and 0.842,respectively,with a higher diagnostic value.Conclusion:For patients with coronary heart disease,serum bilirubin and UA levels have a significant diagnostic value;the higher level of cardiac function in patients with coronary heart disease indicate the higher UA level and the lower serum bilirubin level.UA and serum bilirubin can be used as important indicators for diagnosis and assessment of coronary heart disease,and guiding the development of reasonable treatment programs by clinicians.