N-月桂酰基丙氨酸钠的绿色合成工艺研究

Research on Green Synthesis Process of Sodium N-Lauroyl Alanine

以月桂酸、丙氨酸和氢氧化钠为原料,在特定的加料顺序及过程控制下,无溶剂体系中直接一步法合成了N-月桂酰基丙氨酸钠,利用FT-IR、ESI-MS手段确认了产物的分子结构。对搅拌条件、投料比、反应温度及时间等影响因素进行考察,优化条件摩尔比为月桂酸∶丙氨酸∶固体氢氧化钠=1.00︰1.15︰1.10,180℃下反应18 h,此时产品的副产物皂(月桂酸钠)含量低至0.62%。

Based on laurein,alanine,and sodium hydroxide as the raw material,under the control of specific feeding sequence and process control,sodium N-laurel-based alanine is synthesized in one step in the solventless system.The molecular structure of the product was confirmed by FT-IR and ESI-MS.The influencing factors such as stirring conditions,feed ratio,reaction temperature and time were investigated.The optimum conditions were as follows:the molar ratio of lauric acid:alanine:solid sodium hydroxide=1.00:1.15:1.10,and the reaction time was 18 h at 180℃,the content of by product-soap(sodium laurate)in the product was as low as 0.62%under this condition.