聚乙二醇系列产品中甲醛、乙醛、丙醛含量的测定

Determination of Formaldehyde,Acetaldehyde and Propanal Content in Polyethylene Glycol Series Products

利用O-(4-硝基苄)羟基胺盐酸盐为衍生化剂与试样中的羰基化合物反应生成肟,建立了柱前衍生、以十八烷基硅烷作为固定相,利用紫外检测器在280 nm处测定聚乙二醇系列产品中醛类物质的高效液相色谱法,考察了样品衍生化条件,绘制甲醛-肟、乙醛-肟及丙醛-肟的外标法曲线。实验结果表明,聚乙二醇中的残留羰基化合物经衍生化后可实现较好分离,本方法回收率为96%,检测限为1 mg/kg。此方法具有测定范围广、检测限线低等优点,适用于对聚乙二醇系列产品中甲醛、乙醛、丙醛的质控分析。

Using O-(4-nitrobenzyl)hydroxyamine hydrochloride as derivatizing agent to react with carbonyl compounds in the sample to generate oxime,a high performance liquid chromatography method was established for pre-column derivatization,using octadecyl silane as the stationary phase and using ultraviolet detector to determine aldehydes in polyethylene glycol series products at 280nm.The derivatization conditions of the samples were investigated,and the external standard curves of formaldehyde-oxime,acetaldehyde-oxime and propionaldehyde-oxime were drawn.The experimental results show that the residual carbonyl compounds in polyethylene glycol can be well separated after derivatization,and the recovery rate of this method is 96%,and the detection limit is 1mg/kg.This method has the advantages of wide measurement range and low detection limit,and is suitable for the quality control analysis of formaldehyde,acetaldehyde and propionaldehyde in polyethylene glycol series products.