MPV、PLT及PDW水平与卵圆孔未闭相关偏头痛患者的相关性分析

Correlation between MPV,PLT and PDW levels and migraine patients with patent foramen ovale

目的探讨平均血小板体积(MPV)、血小板计数(PLT)、血小板分布宽度(PDW)与卵圆孔未闭相关偏头痛患者的相关性分析。方法回顾性选取2021年11月至2022年10月沧州市人民医院收治的80例卵圆孔未闭相关偏头痛患者作为研究对象,所有患者均给予封堵术治疗,根据术后头痛影响测定量表-6(HIT-6)评分≥55分为未缓解组(n=39),<55分为缓解组(n=41)。检查并对比两组患者术前、术后MPV、PLT及PDW水平,采用Spearman相关性分析MPV、PLT及PDW水平与HIT-6评分的相关性;Logistic回归分析卵圆孔未闭相关偏头痛患者术后偏头痛未缓解危险因素;采用受试者工作特征(ROC)曲线分析术前MPV、PLT、PDW水平预测卵圆孔未闭相关偏头痛患者术后偏头痛未缓解的价值。结果未缓解组术前MPV、PLT及PDW水平分别为(10.21±1.26)fL、(231.64±22.64)×10^(9)/L、(17.64±1.15)fL,术后MPV、PLT及PDW水平分别为(10.02±0.64)fL、(198.34±23.67)×10^(9)/L、(16.49±1.34)fL,均明显高于缓解组[术前:(9.52±1.13)fL、(201.64±23.67)×10^(9)/L、(16.37±1.03)fL,术后:(9.03±0.69)fL、(174.63±20.64)×10^(9)/L、(15.22±1.14)fL],差异均有统计学意义(P<0.05)。进行Spearman检验得知,MPV、PLT、PDW水平与HIT-6评分存在正相关性(r=0.567、0.491、0.557,P<0.05)。经过ROC分析证实,术前MPV、PLT、PDW水平可预测卵圆孔未闭相关偏头痛患者术后偏头痛未缓解,曲线下面积分别为0.742、0.785、0.827(P<0.05)。经多因素Logistic回归分析证实,MPV≥9.881 fL、PLT≥221.257×10^(9)/L、PDW≥16.919 fL均是卵圆孔未闭相关偏头痛患者术后偏头痛未缓解的危险因素(P<0.05)。结论高水平的MPV、PLT及PDW与卵圆孔未闭相关偏头痛术后影响存在一定关系,术前MPV、PLT及PDW可作为卵圆孔未闭相关偏头痛患者术后偏头痛未缓解的预测指标,且MPV≥9.881 fL、PLT≥221.257×10^(9)/L、PDW≥16.919 fL均是卵圆孔未闭相关偏头痛患者术后偏头痛未缓解的危险因素。

Objective To explore the correlation between mean platelet volume(MPV),platelet distribution width(PDW),platelet count(PLT)and patients with patent foramen ovale related migraine.Methods Eighty patients with patent foramen ovale related migraine admitted to Cangzhou City People's Hospital from November 2021 to October 2022 were retrospectively selected as the study objects.All patients were treated with occlusion.According to the postoperative headache impact test-6(HIT-6)score≥55,they were divided into non remission group(n=39)and remission group(n=41).The levels of MPV,PLT and PDW before and after surgery were examined and compared between the two groups.The correlation between MPV,PLT,and PDW levels and HIT-6 scores using Spearman correlation;the risk factors of unrelieved migraine in patients with patent foramen ovale related migraine after surgery was analyzed using Logistic regression analysis;the value of preoperative MPV,PLT and PDW in predicting postoperative non-remission of migraine in patients with patent foramen ovale related migraine was analyzed by receiver operating characteristic(ROC).Results The levels of preoperative MPV,PLT,and PDW in the non remission group were(10.21±1.26)fL,(231.64±22.64)×10^(9)/L,(17.64±1.15)fL,respectively,the levels of postoperative MPV,PLT,and PDW were(10.02±0.64)fL,(198.34±23.67)×10^(9)/L and(16.49±1.34)fL,respectively,which were significantly higher than those in the remission group[preoperative:(9.52±1.13)fL,(201.64±23.67)×10^(9)/L,(16.37±1.03)fL,postoperative:(9.03±0.69)fL,(174.63±20.64)×10^(9)/L,(15.22±1.14)fL,the differences were statistically significant(P<0.05).Spearman test showed that MPV,PLT,PDW levels were positively correlated with HIT-6 scores(r=0.567,0.491,0.557;P<0.05).ROC analysis proved that preoperative MPV,PLT and PDW levels could predict postoperative migraine failure in patients with patent foramen ovale related migraine,and the areas under the curve were 0.742,0.785 and 0.827,respectively(P<0.05).Multi factor logistic regression analysis confirmed that MPV≥9.881 fL,PLT≥221.257×10^(9)/L and PDW≥16.919 fL were the risk factors of unrelieved migraine in patients with patent foramen ovale related migraine(P<0.05).Conclusion There is a certain relationship between high-level MPV,PLT,and PDW and the postoperative impact of migraine related to patent foramen ovale.Preoperative MPV,PLT and PDW can be used as predictors of postoperative migraine failure in patients with patent foramen ovale associated migraine.And MPV≥9.881 fL,PLT≥221.257×10^(9)/L and PDW≥16.919 fL were all risk factors for non-remission of postoperative migraine in patients with patent foramen oval-related migraine.