术前中性粒细胞与淋巴细胞比值与卵巢癌手术患者预后的关系

Relationship between preoperative neutrophil-to-lymphocyte ratio and prognosis of ovarian cancer patients undergoing surgery

目的 探讨术前中性粒细胞与淋巴细胞比值(NLR)与卵巢癌手术患者预后的关系。方法 收集104例卵巢癌患者的病历资料,卵巢癌患者预后的影响因素采用多因素Logistic分析;绘制受试者工作特征(ROC)曲线,计算曲线下面积(AUC),评估术前NLR对卵巢癌手术患者预后的预测价值。结果 104例卵巢癌患者中,预后良好52例,预后不良52例,预后良好与预后不良卵巢癌手术患者术前NLR、国际妇产科联盟(FIGO)分期比较,差异均有统计学意义(P﹤0.01)。多因素Logistic回归分析结果显示,术前NLR升高、FIGO分期为Ⅲ~Ⅳ期均为卵巢癌手术患者预后不良的独立危险因素(P﹤0.01)。术前NLR预测卵巢癌手术患者预后的AUC为0.790(95%CI:0.703~0.877),预测价值中等,此时的灵敏度为57.69%,特异度为90.38%,cut-off值为4.270。结论 术前NLR≥4.270、FIGO分期为Ⅲ~Ⅳ期均是卵巢癌手术患者不良预后的独立危险因素,应根据患者的具体情况给予围手术期综合辅助治疗,以改善患者预后。

Objective To investigate the relationship between preoperative neutrophil-to-lymphocyte ratio(NLR)and prognosis of ovarian cancer patients undergoing surgery.Method Collected medical records of 104 ovarian cancer pa-tients,and analyzed the prognostic influencing factors of ovarian cancer patients using multivariate Logistic analysis.Drew the receiver operating characteristic(ROC)curve,calculated the area under the curve(AUC),and evaluated the pre-dictive value of preoperative NLR on the prognosis of ovarian cancer patients undergoing surgery.Result Among 104 ovarian cancer patients,52 had good prognosis and 52 had poor prognosis.The preoperative NLR and International Feder-ation of Gynecology and Obstetrics(FIGO)staging of ovarian cancer patients with good and poor prognosis were statisti-cally significant(P<0.01).Multivariate Logistic regression analysis showed that preoperative NLR increased and FIGO stage III-IV were independent risk factors for poor prognosis in patients with ovarian cancer undergoing surgery(P<0.01).The AUC of preoperative NLR in predicting prognosis of ovarian cancer surgery patients was 0.790(95%CI:0.703-0.877),with moderate predictive value,at this time,the sensitivity was 57.69%,the specificity was 90.38%,and the cut-off value was 4.270.Conclusion Preoperative NLR≥4.270 and FIGO stage III-IV are independent risk factors for poor prognosis in ovarian cancer patients undergoing surgery.Perioperative comprehensive adjuvant treatment should be given according to the specific situation of the patient to improve their prognosis.