基质金属蛋白酶14在肿瘤中的研究进展

Research progress of matrix metalloproteinase 14 in tumor

基质金属蛋白酶(MMP)是一组锌依赖的蛋白水解酶,在肿瘤进展过程中可通过降解细胞外基质和基底膜的方式促进肿瘤细胞的侵袭和远处转移。在MMP家族成员中,MMP-14在肿瘤侵袭和血管生成过程中起重要作用,其不仅能够破坏肿瘤周围组织的屏障,亦是促进肿瘤细胞增殖、减少凋亡的关键调控因子。近年来,关于MMP-14在肿瘤中的研究越来越广,靶向MMP-14有望成为抑制肿瘤进展、阻止肿瘤细胞远处转移的有效治疗方式。该文就MMP-14促进肿瘤进展、转移及其干预手段的相关研究进展做一综述。

Matrix metalloproteinases(MMP)constitute a class of zinc-dependent proteolytic enzymes that play a crucial role in facilitating tumor cell invasion and distant metastasis.This is achieved through the degradation of the extracellular matrix and basement membrane,which occurs during the progression of tumors.Among the family members of MMP,MMP-14 assumes a crucial role in facilitating tumor invasion and angiogenesis.It possesses the ability to not only disrupt the integrity of the surrounding tissue barrier of the tumor,but also serves as a crucial regulatory factor that facilitates the proliferation of tumor cells while simultaneously inhibiting apoptosis.In recent years,there has been a significant increase in research focused on MMP-14 in tumors.This growing body of research suggests that targeting MMP-14 holds promise as an effective treatment strategy for inhibiting tumor progression and preventing the spread of tumor cells to distant sites.This article provides a comprehensive review of the research advancements pertaining to MMP-14’s role in facilitating tumor progression,metastasis,and the various intervention strategies employed to target it.