老年维持性血液透析病人前瞻记忆现状调查

A survey of prospective memory in elderly patients undergoing maintenance hemodialysis

目的本研究旨在探索老年维持性血液透析(MHD)病人前瞻性记忆(PM)水平,并探讨其相关影响因素。方法纳入东南大学附属中大医院血液净化中心老年病人60例为MHD组,与其年龄匹配的非MHD人群60例为对照组。对2组对象分别进行神经心理学评估,包括MMSE、语言流畅性测试(VFT)、数字广度测试(DST)、Rey听觉语言学习测试(RAVLT)、Stroop颜色词干扰测试(SCWT),以及基于时间(TB)的前瞻记忆任务测试(TBPM)和基于事件的前瞻记忆任务测试(EBPM)。结果2组在DST中的表现差异无统计学意义(P>0.05)。MHD组MMSE得分低于对照组(P<0.01),SCWT反应时间长于对照组(P<0.01),RAVLT(长时延迟回忆)及VFT(水果)中的表现差于对照组(P<0.01)。MHD组EBPM、TBPM得分和查看时钟频次均显著低于对照组(P<0.01)。结论老年MHD病人存在EBPM和TBPM下降,对其进行PM评估可能有助于筛查认知功能障碍。

Objective To explore the characteristics of prospective memory(PM)in the elderly patients undergoing maintenance hemodialysis(MHD),and to explore the influencing factors.Methods A total of 60 elderly patients in Blood Purification CenteRof Zhongda Hospital were enrolled as the MHD group,and 60 elderly community residents matched by age who did not receive MHD were enrolled as the control group.All subjects in the two groups underwent the neuropsychological assessments,including Mini-Mental State Examination(MMSE),verbal fluency test(VFT),digital span test(DST),Rey auditory verbal learning test(RAVLT),Stroop color-word test(SCWT),event-based prospective memory(EBPM)and time-based prospective memory(TBPM).Results There was no significant difference in the DST score between the two groups(P>0.05).However,compared with the control group,the MMSE score was loweR(P<0.01),SCWT reaction time was longer,RAVLT and VFT(fruit)scores were lower,EBPM and TBPM scores were lower,and the numbeRof clock checking was significantly loweRin the MHD group(P<0.01).Conclusions EBPM and TBPM are impaired in the elderly MHD patients.PM assessment may be useful in screening cognitive impairment and improving the treatment compliance and prognosis.