连续性血液净化对ICU重症脓毒血症患者的应用效果

Application Effect of Continuous Blood Purification on ICU Patients with Severe Sepsis

目的:分析ICU重症脓毒血症患者接受连续性血液净化治疗的临床效果。方法:选取2019年1月—2022年12月贵州省六盘水市钟山区人民医院收治的重症脓毒血症患者80例为观察对象,根据随机数字表法分为对照组与观察组,各40例。对照组采用常规治疗,观察组在对照组基础上采用连续性血液净化治疗,比较两组患者炎性因子水平、生命体征指标、临床疗效、病情转归情况。结果:治疗后,观察组C反应蛋白、降钙素原与白细胞计数水平低于对照组,差异有统计学意义(P<0.001);治疗后,观察组平均动脉压水平高于对照组,呼吸频率、心率、体温水平低于对照组,差异有统计学意义(P<0.001);观察组治疗总有效率高于对照组,差异有统计学意义(P=0.010);治疗后,观察组急性生理与慢性健康状况量表评分低于对照组,差异有统计学意义(P<0.001);随访6个月,两组患者病死率比较,差异无统计学意义(P>0.05)。结论:经连续性血液净化治疗可有效降低ICU重症脓毒血症患者炎性因子水平,维持生命体征稳定,改善患者病情,降低其病死率,效果显著。

Objective:To analyze the clinical effect of continuous blood purification in ICU patients with severe sepsis.Methods:A total of eighty patients with severe sepsis admitted to Zhongshan District People's Hospital from January 2019 to December 2022 were selected as the observation objects,and were divided into control group and observation group according to random number table method,with forty cases in each group.The control group received conventional treatment,and the observation group received continuous blood purification treatment on the basis of the control group.The levels of inflammatory factors,vital signs,clinical efficacy and disease outcome were compared between the two groups.Results:After treatment,the levels of C-reactive protein,procalcitonin and white blood cell count in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.001);After treatment,the mean arterial pressure in the observation group was higher than that in the control group,and the respiratory rate,heart rate and body temperature were lower than that in the control group,with statistical significance(P<0.001);The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P=0.010);After treatment,the acute physiological and chronic health status scale scores of the observation group were lower than those of the control group,and the difference was statistically significant(P<0.001);After 6 months of follow-up,there was no significant difference in mortality between the two groups(P>0.05).Conclusion:Continuous blood purification treatment can effectively reduce the level of inflammatory factors in ICU patients with severe sepsis,maintain the stability of vital signs,improve the condition of patients,and reduce the mortality,with remarkable effect.