戊酸雌二醇联合米非司酮和米索前列醇治疗稽留流产的临床效果分析

Clinical Effect of Estradiol Valerate Combined with Mifepristone and Misoprostol in the Treatment of Missed Abortion

目的:分析戊酸雌二醇联合米非司酮和米索前列醇治疗稽留流产的临床效果。方法:选取2020年1月—2022年12月桐梓县人民医院收治的120例稽留流产患者为研究对象,依据随机数字表法分对照组和观察组,各60例。对照组给予米非司酮联合米索前列醇治疗,观察组在对照组基础上给予戊酸雌二醇治疗。比较两组患者治疗相关指标、宫颈软化与扩张效果、不良反应发生率、生活质量。结果:观察组药物流产出血量、术中出血量、阴道出血量均少于对照组,清宫术时间、胚胎排出时间、阴道持续出血时间短于对照组,差异有统计学意义(P<0.001);观察组宫颈软化与扩张总有效率高于对照组,差异有统计学意义(P<0.05);观察组生活质量各维度评分及生活质量总分高于对照组,差异有统计学意义(P<0.001)。结论:戊酸雌二醇联合米非司酮及米索前列醇治疗稽留流产效果显著,可减少出血量,提高患者生活质量,强化清宫术效果,不会增加不良反应发生风险。

Objective:To analyze the clinical effect of estradiol valerate combined with mifepristone and misoprostol in the treatment of missed abortion.Methods:A total of one hundred and twenty missed abortion patients admitted to Tongzi County People's Hospital from January 2020 to December 2022 were selected as the study objects,and were divided into control group and observation group according to random number table method,with sixty cases in each group.The control group was given mifepristone combined with misoprostol,and the observation group was given estradiol valerate on the basis of the control group.Treatment related indexes,cervical malacia and dilatation effects,incidence of adverse reactions and quality of life were compared between the two groups.Results:The amount of drug abortion blood loss,intraoperative blood loss and vaginal blood loss in the observation group was less than that in the control group,and the time of uterine clearance operation,embryo discharge time and continuous vaginal bleeding time were shorter than that in the control group,with statistical significance(P<0.001);The total effective rate of cervical malacia and dilation in observation group was higher than that in control group,the difference was statistically significant(P<0.05);The scores of all dimensions of quality of life and total score of quality of life in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.001).Conclusion:Estradiol valerate combined with mifepristone and misoprostol has a significant effect in the treatment of missed abortion,which can reduce the amount of blood loss,improve the quality of life of patients,strengthen the effect of uterine clearance,and do not increase the risk of adverse reactions.