青蒿素和槲皮素抑制新冠病毒刺突蛋白介导的细胞因子风暴

Artemisinin and Quercetin Inhibit Cytokine Storm Mdiated by SARS-CoV-2 Spike Protein

目的研究青蒿素和槲皮素的单独或联合治疗是否能改善新冠病毒(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2)的棘突蛋白(spike protein,S蛋白)介导的细胞因子风暴。方法进行细胞活力测定,而后检测青蒿素或槲皮素单独或联合处理对SARS-CoV-2的S蛋白介导的细胞因子风暴的改善作用。结果在SARS-CoV-2 S蛋白刺激下,青蒿素或槲皮素的单独或联合治疗可以通过抑制NFKB的过度激活来显著减轻细胞因子风暴。结论单独和联合使用青蒿素和槲皮素均能有效地抑制SARS-CoV-2 S蛋白介导的细胞因子风暴。

Objective To investigate whether the single or combined treatments with artemisinin and quercetin can improve.Methods Cell viability was measured,and then the improvement effects on SARS CoV-2 S protein-mediated cytokine storm by artemisinin or quercetin alone or in combination were detected.Results Under the stimulation of SARS CoV-2 S protein,artemisinin or quercetin alone or in combination could significantly alleviate the Cytokine storm by inhibiting the over activation of NFKB.Conclusion Both artemisinin and quercetin alone and in combination can effectively inhibit SARS CoV-2 S protein mediated-cytokine storm.