纳米超粒子的水相制备及生物医学应用

Aqueous Fabrication and Biomedical Applications of Supraparticles

纳米超粒子(Supraparticles,SPs)是指由一种或多种纳米颗粒组装单元,在内、外部驱动力的作用下,自组装形成的具有一定形貌、尺寸和分级结构的纳米实体.由于具有复杂的拓扑结构、丰富的表面可修饰性、可调的集合性质和协同效应,SPs在生物医学等领域具有较大的应用潜力.本文总结了近几年来水相制备SPs的研究进展,包括组装单元之间作用力调制、SPs的物理、化学性质及其在生物成像、疾病诊疗等方面的应用,最后讨论了SPs结构和性能的精准调控、生物医学应用中存在的主要问题以及未来SPs的发展方向.

Supraparticles(SPs)are the nano-entities self-assembled by one or multiple nanoparticle based on internal or external driving forces,which possess specific morphology,definite size,and hierarchical structure.Due to the complex topologies,abundant surface modifiability,tunable collective properties,and synergistic effects,SPs have considerable potentials in the biomedical field.Here,recent progress of SPs synthesized in aqueous phase,including the force modulation between building blocks,the property of SPs,and their applications in biological imaging,disease diagnosis,and therapy,is reviewed.Finally,the main challenges and future advancement in aspects of the precise regulation of the structure and properties of SPs,as well as biomedical applications are discussed.