酸枣仁汤治疗失眠障碍的机制研究进展

Progress on the Mechanism of Insomnia Disorder

失眠是一种常见的睡眠障碍。伴随社会发展,生活节奏加快,竞争压力增大,以失眠为主的睡眠障碍的发生率逐年升高,已成为严重的公共卫生问题。目前中医药作为治疗失眠障碍的替代方法,良好的治疗效果逐渐引起临床医生的重视。酸枣仁汤是一种常见的中药方剂,可通过多种机制来发挥治疗失眠的作用,包括调节中枢神经递质和免疫细胞因子水平、调节下丘脑-垂体-肾上腺轴功能、调控昼夜节律相关的基因、参与星形胶质细胞的调节以及影响营养物质的代谢等。本文就酸枣仁汤治疗失眠障碍的相关机制进行综述。

Insomnia is a common sleep disorder.With the development of society,accelerated pace of life and increased competitive pressure,the incidence of sleep disorders,mainly insomnia,is increasing year by year and has become a serious public health problem.The good therapeutic effect of Chinese medicine as an alternative method for treating insomnia disorders is now gradually attracting the attention of clinicians.Suanzaoren decoction is a common herbal formula that can exert its effects in treating insomnia through various mechanisms,including regulating central neurotransmitter and immune cytokine levels,modulating hypothalamic-pituitary-adrenal axis,regulating circadian rhythm-related genes,participating in astrocyte regulation,and affecting nutrient metabolism.We review the mechanisms of suanzaoren decoction in treating insomnia disorders.