The antiferroptotic role of TRIM7:Molecular mechanism and synergistic effect with temozolomide

Ferroptosis is a distinct form of regulated cell death characterized by the accumulation of lipid peroxides and iron-dependent membrane damage that is a significant contributor to drug resistance in glioblastoma(GBM).Dysregulated iron metabolism is a hallmark of cancer,making ferroptosis a unique potential target for anticancer therapy.Ferritinophagy,the selective autophagy of ferritin,plays an essential role in cellular iron homeostasis and may impact the vulnerability of cells to ferroptosis.Nuclear receptor coactivator 4(NCOA4)protein is a selective cargo receptor that plays a crucial role in ferritinophagy by targeting and delivering the ferritin iron storage protein to the lysosome for degradation,releasing iron[1].However,the underlying molecular mechanism that causes reduced NCOA4 expression in glioma is not fully understood.