广西长寿老人高敏C反应蛋白与代谢综合征的相关性

Correlation between high-sensitivity C-reactive protein and metabolic syndrome in Guangxi longevous people

目的基于广西自然长寿队列,分析长寿老人血清高敏C反应蛋白(hs-CRP)水平与代谢综合征(MS)及其相关代谢性疾病的相关性。方法2019年7月至11月,选择广西东兴市和上林县265例90岁及以上长寿老人为研究对象,逐户采集一般人口学指标、身高、体质量、腰围、血压、空腹血糖、血脂和hs-CRP等数据。根据研究对象是否患有MS将其分为MS组(68例)和非MS组(197例);根据研究对象hs-CRP水平将患者分为hs-CRP≥3 mg/L组(160例)和hs-CRP<3 mg/L组(105例)。采用SPSS 21.0统计软件进行数据分析。根据数据类型,分别采用t检验、Mann-Whitney U检验、χ^(2)检验或Fisher精确检验进行组间比较。采用多因素logistic回归分析hs-CRP与MS及其相关代谢性疾病的关系。结果MS组hs-CRP水平显著高于非MS组,差异有统计学意义(P<0.05)。hs-CRP≥3 mg/L的长寿老人高低密度脂蛋白胆固醇(LDL-C)血症、血脂异常和MS患病率显著高于非MS组(P<0.05);高血压患病率显著低于非MS组(P<0.05)。hs-CRP≥3 mg/L的长寿老人发生MS(OR=2.173,95%CI 1.151~4.106)、血脂异常(OR=2.003,95%CI 1.128~3.555)、高甘油三酯(TG)血症(OR=2.139,95%CI 1.013~4.518)、高LDL-C血症(OR=3.821,95%CI 1.319~11.072)风险增加,发生高血压的风险降低(OR=0.282,95%CI 0.087~0.908)。结论长寿老人的血清hs-CRP水平与MS、血脂异常、高TG血症和高LDL-C血症、高血压有相关性,hs-CRP升高者患MS的风险增加。

Objective To analyze the correlation of serum high-sensitivity C-reactive protein(hs-CRP)level with metabolic syndrome(MS)and related metabolic diseases in the longevous people based on the Guangxi Natural longevity cohort.Methods A total of 265 longevous people aged 90 years and above living in Dongxing City and Shanglin County,Guangxi were enrolled during July to November 2019.Their demographic data,height,body mass,waist circumference,blood pressure,fasting blood glucose,blood lipids and hs-CRP levels were collected by house-to-house survey.The participants were divided into MS group(n=68)and non-MS group(n=197)according to whether they had MS or not,and also into hs-CRP≥3 mg/L group(n=160)and hs-CRP<3 mg/L group(n=105)according to their hs-CRP levels.SPSS statistics 21.0 was used for data analysis.Student′s t test,Mann-Whitney U test,Chi-square test or Fisher exact test was employed for intergroup comparison,and multivariate logistic regression analysis was performed to analyze the relationship of hs-CRP with MS and its related metabolic diseases.Results The level of hs-CRP was significantly higher in the MS group than the non-MS group(P<0.05).The elderly with hs-CRP≥3mg/L had higher ratios of hyper-low-density lipoprotein cholesterolemia,dyslipidemia and MS(P<0.05),and lower prevalence of hypertension than those from the non-MS group(P<0.05).They were also at risks of MS(OR=2.173,95%CI 1.151-4.106),dyslipidemia(OR=2.003,95%CI 1.128-3.555),hypertriglyceridemia(OR=2.139,95%CI 1.013-4.518),and hyper-low-density lipoprotein cholesterolemia(OR=3.821,95%CI 1.319-11.072),but at reduced risk of hypertension(OR=0.282,95%CI 0.087-0.908).Conclusion Serum hs-CRP level in longevous people are associated with MS,dyslipidemia,hypertriglyceridemia,hyper-low-density lipoprotein cholesterolemia and hypertension,and those with elevated hs-CRP are at increased risk of MS.