细胞焦亡在脑出血发病机制中的研究进展

Research progress in pyroptosis in pathogenesis of cerebral hemorrhage

细胞焦亡是一种新型细胞程序化凋亡,在发生细胞焦亡时,细胞膜受外界因素刺激出现破裂,细胞开始膨胀,胞液经由破裂的间隙外流,炎症因子生成,引发炎症反应,后期细胞崩解。细胞焦亡在神经系统性疾病、传染性疾病、自体免疫病和心血管疾病等疾病领域内均有所研究。本文以细胞焦亡的机制、其在脑出血中的相关功能及与细胞焦亡有关的关键因子为出发点,结合当下的最新研究结果进行综述,进一步探索脑出血的病理机制,以期为脑出血的研究和医治开辟新道路。

Pyroptosis is a new type of programmed apoptosis of cells.During pyroptosis,the cell membrane bursts due to the stimulation of external factors,the cell begins to expand,cellular fluid flows out through the pores,inflammatory factors are generated to trigger inflammation,and the cell collapses in the later stage.Pyroptosis has been studied in the fields of neurosystemic diseases,infectious diseases,autoimmune diseases,and cardiovascular diseases.This article reviews the latest research findings of pyroptosis based on its mechanism,its role in cerebral hemorrhage and some key factors,to further explore the pathological mechanism of cerebral hemorrhage,hoping to provide a new approach to the research and treatment of cerebral hemorrhage.