2型糖尿病患者结直肠癌的发生风险和潜在机制

Risk of occurrence and potential mechanisms of colorectal cancer in patients with type 2 diabetes mellitus

流行病学研究发现,糖尿病与自身免疫性疾病、肿瘤等众多疾病的发生和发展有关,与非糖尿病人群相比,糖尿病人群患肿瘤等疾病的概率更大,症状更重,预后更差。结直肠癌(CRC)是消化系统中常见的恶性肿瘤,也是威胁我国居民生命健康及造成人民生活质量下降的主要癌症之一。近年来,糖尿病尤其是2型糖尿病(T2DM)与结直肠癌的关系受到越来越多的关注。其中受学者最为关注的一点是T2DM可作为CRC的独立影响因素,这可能与胰岛素抵抗、高血糖、炎症反应、外源性胰岛素等有关。本文对2型糖尿病患者结直肠癌的发生风险及潜在机制进行综述。

Epidemiology has found that diabetes mellitus is related to the occurrence and development of autoimmune diseases,tumors and other diseases,and that diabetic people are more prone to such diseases as tumors,and have more severe symptoms and worse prognosis than non-diabetic people.Colorectal cancer(CRC)is a common malignant tumor in the digestive system and one of the main cancers that threaten the life and health of Chinese and cause a decline in their quality of life.Relationship between diabetes,type 2 diabetes mellitus(T2DM)in particular,and CRC has drew increasing attention in recent years.The biggest concern by scholars is that T2DM can be an independent influencing factor of CRC,and this may be related to insulin resistance,hyperglycemia,inflammation,and exogenous insulin.This article reviews the correlation between T2DM and colorectal cancer and the potential mechanisms.